E
Enrico De Smaele
Researcher at Sapienza University of Rome
Publications - 73
Citations - 6149
Enrico De Smaele is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Hedgehog & GLI1. The author has an hindex of 35, co-authored 66 publications receiving 5533 citations. Previous affiliations of Enrico De Smaele include University of Chicago & University of Illinois at Chicago.
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Journal ArticleDOI
Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling
Enrico De Smaele,Francesca Zazzeroni,Salvatore Papa,Dung U. Nguyen,Rongguan Jin,Joy Jones,Rong Cong,Guido Franzoso +7 more
TL;DR: It is reported that NF-κB complexes downregulate the c-Jun amino-terminal kinase (JNK) cascade, thus establishing a link between the NF-σκB and the JNK pathways and establishing a role for the persistent activation of JNK in the apoptotic response to TNF-α.
Journal ArticleDOI
Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen Species
Can G. Pham,Concetta Bubici,Francesca Zazzeroni,Salvatore Papa,Joy Jones,Kellean Alvarez,Shanthi Jayawardena,Enrico De Smaele,Rong Cong,Carole Beaumont,Frank M. Torti,Suzy V. Torti,Guido Franzoso +12 more
TL;DR: Modulation of FHC or of iron metabolism as a potential approach for anti-inflammatory therapy is suggested and a basis for the NF-κB-mediated control of ROS induction is established.
Journal ArticleDOI
Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2.
Salvatore Papa,Francesca Zazzeroni,Concetta Bubici,Shanthi Jayawardena,Kellean Alvarez,Shuji Matsuda,Dung U. Nguyen,Can G. Pham,Andreas H. Nelsbach,Tiziana Melis,Enrico De Smaele,Wei Jen Tang,Luciano D'Adamio,Guido Franzoso +13 more
TL;DR: A basis for the NF-κB control of JNK activation is established and MKK7/JNKK2 is identified as a potential target for anti-inflammatory and anti-cancer therapy.
Journal ArticleDOI
Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells
Elisabetta Ferretti,Enrico De Smaele,Evelina Miele,Pietro Laneve,Agnese Po,Marianna Pelloni,Arianna Paganelli,Lucia Di Marcotullio,Elisa Caffarelli,Isabella Screpanti,Isabella Screpanti,Irene Bozzoni,Irene Bozzoni,Alberto Gulino,Alberto Gulino +14 more
TL;DR: Whereas miRNA expression is downregulated in cerebellar neuronal progenitors, it increases alongside differentiation, thereby allowing cell maturation and growth inhibition, and it is suggested that misregulation of specific miRNAs, leading to its aberrant activation, sustain cancer development.
Journal ArticleDOI
Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation
Gianluca Canettieri,Lucia Di Marcotullio,Azzura Greco,Sonia Coni,Laura Antonucci,Paola Infante,Laura Pietrosanti,Enrico De Smaele,Elisabetta Ferretti,Evelina Miele,Marianna Pelloni,Giuseppina De Simone,Emilia Pedone,Paola Gallinari,Alessandra Giorgi,Christian Steinkühler,Luigi Vitagliano,Carlo Pedone,M Eugenià Schinin,Isabella Screpanti,Alberto Gulino +20 more
TL;DR: It is shown that Gli1 and Gli2 are acetylated proteins and that their HDAC-mediated deacetylation promotes transcriptional activation and sustains a positive autoregulatory loop through Hedgehog-induced upregulation of HDAC1.