This review reports the progress on the recent development of micromixers. The review first presents the different micromixer types and designs. Micromixers in this review are categorized as passive micromixers and active micromixers. Due to the simple fabrication technology and the easy implementation in a complex microfluidic system, passive micromixers will be the focus of this review. Next, the review discusses the operation points of the micromixers based on characteristic dimensionless numbers such as Reynolds number Re, Peclet number Pe, and in dynamic cases the Strouhal number St. The fabrication technologies for different mixer types are also analysed. Quantification techniques for evaluation of the performance of micromixers are discussed. Finally, the review addresses typical applications of micromixers.

https://iopscience.iop.org/article/10.1088/0960-1317/15/2/R01/pdf

Micromixers?a review

Nanotechnology is the science of understanding matter and the control of matter at dimensions of 100 nm or less. Encompassing nanoscale science, engineering, and technology, nanotechnology involves imaging, measuring, modeling, and manipulation of matter at this level of precision. An important aspect of research in nanotechnology involves precision control and manipulation of devices and materials at a nanoscale, i.e., nanopositioning. Nanopositioners are precision mechatronic systems designed to move objects over a small range with a resolution down to a fraction of an atomic diameter. The desired attributes of a nanopositioner are extremely high resolution, accuracy, stability, and fast response. The key to successful nanopositioning is accurate position sensing and feedback control of the motion. This paper presents an overview of nanopositioning technologies and devices emphasizing the key role of advanced control techniques in improving precision, accuracy, and speed of operation of these systems.

/pdf/a-survey-of-control-issues-in-nanopositioning-1zgjre9s1l.pdf

A Survey of Control Issues in Nanopositioning

This article reviews acoustic microfiuidics: the use of acoustic fields, principally ultrasonics, for application in microfiuidics. Although acoustics is a classical field, its promising, and indeed perplexing, capabilities in powerfully manipulating both fluids and particles within those fluids on the microscale to nanoscale has revived interest in it. The bewildering state of the literature and ample jargon from decades of research is reorganized and presented in the context of models derived from first principles. This hopefully will make the area accessible for researchers with experience in materials science, fluid mechanics, or dynamics. The abundance of interesting phenomena arising from nonlinear interactions in ultrasound that easily appear at these small scales is considered, especially in surface acoustic wave devices that are simple to fabricate with planar lithography techniques common in microfluidics, along with the many applications in microfluidics and nanofluidics that appear through the literature.

/pdf/microscale-acoustofluidics-microfluidics-driven-via-5bet39j13p.pdf

Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics

The aim of microfluidic mixing is to achieve a thorough and rapid mixing of multiple samples in microscale devices. In such devices, sample mixing is essentially achieved by enhancing the diffusion effect between the different species flows. Broadly speaking, microfluidic mixing schemes can be categorized as either “active”, where an external energy force is applied to perturb the sample species, or “passive”, where the contact area and contact time of the species samples are increased through specially-designed microchannel configurations. Many mixers have been proposed to facilitate this task over the past 10 years. Accordingly, this paper commences by providing a high level overview of the field of microfluidic mixing devices before describing some of the more significant proposals for active and passive mixers.

/pdf/microfluidic-mixing-a-review-3egj61w5ox.pdf

Microfluidic Mixing: A Review

The ability to tailor the chemical composition and structure of a surface at the sub-100-nm length scale is important for studying topics ranging from molecular electronics to materials assembly, and for investigating biological recognition at the single biomolecule level. Dip-pen nanolithography (DPN) is a scanning probe microscopy-based nanofabrication technique that uniquely combines direct-write soft-matter compatibility with the high resolution and registry of atomic force microscopy (AFM), which makes it a powerful tool for depositing soft and hard materials, in the form of stable and functional architectures, on a variety of surfaces. The technology is accessible to any researcher who can operate an AFM instrument and is now used by more than 200 laboratories throughout the world. This article introduces DPN and reviews the rapid growth of the field of DPN-enabled research and applications over the past several years.

Applications of dip-pen nanolithography.

A collaborative effort is aimed at the development of reconfigurable array technology. The goal is to enable innovative medical ultrasound imagers ideally suited for portable ultrasound and applications such as remote emergency medicine and combat casualty care. Success depends on developing several technologies, the first of which is capacitive micromachined ultrasound transducers (cMUTs). The monolithic nature of cMUTs facilitates close connection with microelectronics. Thus a second technology under development is a switch matrix application specific integrated circuit (ASIC) that will enable the changing of interconnect between cMUT cells. The reconfigurable array concept arises from this ability to dynamically combine cMUT cells to form ideal apertures for a given imaging target (e.g. annular and phased apertures of various ring widths) and to move these apertures across the reconfigurable array plane [1-4]. Two central hypotheses are being tested: (1) the reconfigurable array can acquire acoustic pulse-echo data in a manner equivalent or superior to today’s 1D piezoceramic arrays (2) reconfigurable array technology will enable highly portable ultrasound platforms. Keywords-reconfigurable; annular; array; cMUT; ASIC; switch matrix; dynamic; phased; real-time

Reconfigurable arrays for portable ultrasound

There is described a method and apparatus for measuring temperature of a fluid in a microchannel of the type having spaced walls. An ultrasonic transducer transmits ultrasonic waves transmitted from one wall to the opposite wall. A processor determines the time-of-flight of the ultrasonic waves from the one wall and reflected to the opposite wall to the one wall. The processor converts the time-of-flight to velocity by dividing the distance between walls by the time-of-flight. The processor converts velocity to temperature from the relationship of velocity to temperature in the fluid.

Microfluidic channels with integrated ultrasonic transducers for temperature measurement and method

Capacitive Micromachined Ultrasonic Lamb Wave Transducers Using Rectangular

Equivalent circuit model has been widely used to predict the bandwidth of capacitive micromachined ultrasonic transducers (CMUTs). According to this model, the lower cutoff of the bandwidth is determined by the time constant of the parallel RC where R is dictated by the radiation and C is determined by the electrical capacitance of the transducer. The higher cutoff, on the other hand, is determined by the membrane's anti-resonance. In the mechanical part of the model, the radiation impedance is simply added to the membrane impedance assuming that the membrane impedance does not change when it operates in the immersion medium. Therefore, the mass loading effect of the medium is neglected. Our finite element method calculations showed that the mass loading on the membrane impedance drastically lowers the membrane anti-resonance frequency degrading the bandwidth. In this paper, we present results of equivalent circuit modeling combined with finite element analysis. We constructed a 3D finite element model for one element of a 1D array. The element has 7 hexagonal membranes in the width dimension and it is assumed that the membranes are replicated in the length dimension infinitely by using symmetry boundary conditions. By combining membrane impedance with equivalent circuit model, we found that the center frequency of operation is 11 MHz and the bandwidth is 12.5 MHz close to the collapse voltage. We also investigated the effect of the DC bias on the center frequency. Decreasing the bias voltage increased the center frequency without affecting the bandwidth assuming the source impedance is zero.

Improved equivalent circuit and finite element method modeling of capacitive micromachined ultrasonic transducers

The characterization of two-dimensional micromachined silicon cantilever arrays with integrated through-wafer electrical interconnects is presented. The approach addresses alignment and density issues associated with operating two-dimensional scanning probe arrays. The tungsten based interconnect (30 μm diameter, 1 Ω resistance) is shown not to degrade the sensitivity of the piezoresistive deflection sensor embedded on each cantilever. Operation of the array (up to 2×7) as a microscope for imaging large areas (3.8×0.45 mm2) and with vertical row stitching is demonstrated with images of samples orders of magnitude larger than images possible with standard atomic force microscope techniques.

Goksen G. Yaralioglu

Papers

Reconfigurable arrays for portable ultrasound

Microfluidic channels with integrated ultrasonic transducers for temperature measurement and method

Capacitive Micromachined Ultrasonic Lamb Wave Transducers Using Rectangular

Improved equivalent circuit and finite element method modeling of capacitive micromachined ultrasonic transducers

Characterization of a two-dimensional cantilever array with through-wafer electrical interconnects