Gordon Broderick

TL;DR: Myalgic encephalomyelitis: International Consensus Criteria (Review).

TL;DR: The simulated effect of crowding on barnase-barstar dimerization, an experimentally characterized example of a bimolecular association reaction, reveals a biphasic time course, indicating that crowding exerts different effects over different timescales, and illustrates that quantitative realism in biosimulation will depend to some extent on mesoscale phenomena that are not currently well understood.

TL;DR: Many transcriptome changes previously described in rejection are features of a large‐scale disturbance characteristic of rejection but occurring at lower levels in many forms of injury, indicating that transcriptome disturbances in renal transplants have a stereotyped internal structure.

TL;DR: Network analysis to the co-expression of 16 cytokines in CFS subjects and healthy controls identifies key sub-networks such as IL-2:IFN-γ:TNF-α that might be targeted in restoring normal immune function.

TL;DR: It is proposed that new insight will depend on the ability to develop and deploy an integrative profiling of CFS/ME pathogenesis at the molecular level, and until such a molecular signature is obtained efforts to develop effective treatments will continue to be severely limited.