G
Govindasamy Mugesh
Researcher at Indian Institute of Science
Publications - 181
Citations - 9826
Govindasamy Mugesh is an academic researcher from Indian Institute of Science. The author has contributed to research in topics: Glutathione peroxidase & Iodothyronine deiodinase. The author has an hindex of 46, co-authored 173 publications receiving 8278 citations. Previous affiliations of Govindasamy Mugesh include Indian Institutes of Technology & University of Washington.
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Selenenyl iodide: a new substrate for mammalian thioredoxin reductase
TL;DR: In this paper, a stable selenenyl iodide stabilised by internal chelation has been synthesized and evaluated as a substrate of thioredoxin reductase (TrxR).
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2‐(4′,4′‐Dimethyl‐3′,4′‐dihydrooxazol‐2′‐yl)phenol: Some First‐Row Transition Metal Complexes of This Naturally Occurring Binding Group
TL;DR: The synthesis and characterization of monomeric Mn III, Co II, Ni II, Cu II, and Zn II phenolates derived from a biologically relevant ligand was described in this paper.
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Interaction of anti-thyroid drugs with iodine: the isolation of two unusual ionic compounds derived from Se-methimazole
TL;DR: This study provides the first experimental evidence that MSeI not only effectively inhibits the LPO-catalyzed iodination of tyrosine, but also reacts with I(2) to produce novel ionic diselenides.
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Combining benzo[d]isoselenazol-3-ones with sterically hindered alicyclic amines and nitroxides: enhanced activity as glutathione peroxidase mimics.
TL;DR: Benzo[d]isoselenazol-3-ones N-substituted with sterically hindered diamagnetic and paramagnetic five- or six-membered nitroxides or their precursors, including ring-opened diselenides, exhibit synergism in glutathione peroxidase (GPx) activity.
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Antithyroid drug carbimazole and its analogues: synthesis and inhibition of peroxidase-catalyzed iodination of L-tyrosine.
TL;DR: A structure-activity correlation in a series of CBZ analogues suggests that the presence of a methyl substituent in CBZ and related compounds is important for their antithyroid activity.