G
Govindasamy Mugesh
Researcher at Indian Institute of Science
Publications - 181
Citations - 9826
Govindasamy Mugesh is an academic researcher from Indian Institute of Science. The author has contributed to research in topics: Glutathione peroxidase & Iodothyronine deiodinase. The author has an hindex of 46, co-authored 173 publications receiving 8278 citations. Previous affiliations of Govindasamy Mugesh include Indian Institutes of Technology & University of Washington.
Papers
More filters
Journal ArticleDOI
Manganese-Based Nanozymes: Multienzyme Redox Activity and Effect on the Nitric Oxide Produced by Endothelial Nitric Oxide Synthase.
TL;DR: It was found that Mn3 O4 nanoparticles mimic the functions of all three cellular antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and were found to be biocompatible, with very low cytotoxicity.
Journal ArticleDOI
CeVO 4 Nanozymes Catalyze the Reduction of Dioxygen to Water without Releasing Partially Reduced Oxygen Species
Namrata Singh,Govindasamy Mugesh +1 more
TL;DR: A remarkably active CeVO4 nanozyme is reported that functionally mimics cytochrome c oxidase (CcO), the terminal enzyme in the respiratory electron transport chain, by catalyzing a four-electron reduction of dioxygen to water.
Journal ArticleDOI
Tuning seleniumiodine contacts: from secondary soft–soft interactions to covalent bonds
Wolf-Walther du Mont,Andreas Martens-von Salzen,Frank Ruthe,Emma Seppälä,Govindasamy Mugesh,Francesco A. Devillanova,Vito Lippolis,Norbert Kuhn +7 more
TL;DR: In this paper, the authors reviewed the properties of Se and I van der Waals distances to strong covalent bonds with the help of recent structural determinations of compounds exhibiting SeI distances from 384 to 244 pm, with emphasis on less clearcut cases.
Journal ArticleDOI
Redox regulation of protein tyrosine phosphatase 1B (PTP1B): a biomimetic study on the unexpected formation of a sulfenyl amide intermediate.
TL;DR: These studies reveal that the introduction of a substituent at the 6-position of the benzene ring enhances the cyclization process not only by facilitating a closer approach of the -OH group and the backbone -NH moiety but also by increasing the electrophilicity of the sulfur atom in the sulfenic acid.
Journal ArticleDOI
Inhibition of Lactoperoxidase-Catalyzed Oxidation by Imidazole-Based Thiones and Selones: A Mechanistic Study
TL;DR: These experimental and theoretical studies suggest that the selones exist as zwitterions, in which the imidazole ring contains a positive charge and the selenium atom carries a large negative charge, which is 4-12-fold higher than that of the well-known GPx-mimic ebselen.