G
Grace St. Clair
Researcher at DuPont Pioneer
Publications - 10
Citations - 811
Grace St. Clair is an academic researcher from DuPont Pioneer. The author has contributed to research in topics: Gene & Homologous recombination. The author has an hindex of 6, co-authored 10 publications receiving 666 citations.
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Journal ArticleDOI
Engineering Secondary Metabolism in Maize Cells by Ectopic Expression of Transcription Factors
Erich Grotewold,Mark A. Chamberlin,Maurice E. Snook,Bupe A. Siame,Larry G. Butler,Jan Swenson,Sheila Maddock,Grace St. Clair,Ben Bowen +8 more
TL;DR: The results support a simple model showing how the gene encoding P may act as a quantitative trait locus controlling insecticidal C-glycosyl flavone level in maize silks, and suggest how p1 might confer a selective advantage against insect predation in maize.
Journal ArticleDOI
Targeted manipulation of maize genes in vivo using chimeric RNA/DNA oligonucleotides.
TL;DR: Site-specific heritable mutations in maize genes were engineered by introducing chimeric RNA/DNA oligonucleotides, thereby conferring resistance to either imidazolinone or sulfonylurea herbicides and providing a system for studying mismatch repair mechanisms in maize.
Journal ArticleDOI
Superior field performance of waxy corn engineered using CRISPR-Cas9.
Huirong Gao,Mark Jacob Gadlage,H. Renee Lafitte,Brian Lenderts,Meizhu Yang,Megan Schroder,Jeffry Farrell,Kay Snopek,Dave Peterson,Lanie Feigenbutz,Spencer Jones,Grace St. Clair,Melissa Rahe,Nathalie Sanyour-Doyel,Chenna Peng,Lijuan Wang,Joshua K. Young,Mary Beatty,Brian Dahlke,Jan Hazebroek,Thomas W. Greene,A. Mark Cigan,N. Doane Chilcoat,R. Bob Meeley +23 more
TL;DR: Field trials showed that CRISPR-waxy hybrids were agronomically superior to introgressed hybrids, producing on average 5.5 bushels per acre higher yield.
Journal ArticleDOI
Complex Trait Loci in Maize Enabled by CRISPR-Cas9 Mediated Gene Insertion.
Huirong Gao,Jasdeep S. Mutti,Joshua K. Young,Meizhu Yang,Megan Schroder,Brian Lenderts,Lijuan Wang,Dave Peterson,Grace St. Clair,Spencer Jones,Lanie Feigenbutz,Wally Marsh,Min Zeng,Susan Wagner,Jeffry Farrell,Kay Snopek,Christopher J. Scelonge,Xiaoyi Sopko,Jeffry D. Sander,Scott D. Betts,A. Mark Cigan,N. Doane Chilcoat +21 more
TL;DR: It is demonstrated that two traits residing at different sites within a CTL can be combined via genetic recombination, a major step forward in the development of multi-trait maize hybrids.
Journal ArticleDOI
Miniature type V-F CRISPR-Cas nucleases enable targeted DNA modification in cells.
Greta Bigelyte,Joshua K. Young,Tautvydas Karvelis,Karolina Budre,Rimante Zedaveinyte,Vesna Djukanovic,Elizabeth Van Ginkel,Sushmitha Paulraj,Stephen L. Gasior,Spencer Jones,Lanie Feigenbutz,Grace St. Clair,Pierluigi Barone,Jennifer A. Bohn,Ananta Acharya,Gina Zastrow-Hayes,Selgar Henkel-Heinecke,Arunas Silanskas,Ralf Seidel,Virginijus Siksnys +19 more
TL;DR: In this article, the authors characterized two miniature type V-F Cas nucleases, SpCas12f1 (497 aa) and AsCas12 f1 (422 aa), and showed that they function in both plant and human cells to produce targeted modifications with outcomes in plants being enhanced with short heat pulses.