Graciosa Q. Teixeira

TL;DR: This manuscript reviews the existent literature on how preconditioning of MSCs affects the therapeutic potential of their secretome, focusing on MSC's immunomodulatory and regenerative features, thereby providing new insights for the therapeutic use of M SCs' secretome.

TL;DR: The main findings support the success of an anti-inflammatory therapy for degenerated IVD that not only reduces inflammation but also promotes native IVD matrix production and delays and/or decreases ECM degradation.

TL;DR: The present study provides evidence for an immunomodulatory paracrine effect of MSCs in degenerated IVD without an apparent effect in ECM remodeling, and suggest an M SCs mechanism-of-action dependent on a cytokine feedback loop.

TL;DR: The potential of Chitosan (Ch)/Poly(γ-glutamic acid) (γ-PGA) nanoparticles (NPs) to modulate macrophages and DCs inflammatory profile and to impair their ability to promote cancer cell invasion is assessed.

TL;DR: The proinflammatory/degenerative IVD organ culture model established can be considered a suitable approach for testing novel therapeutic drugs, thus reducing the number of animals in in vivo experimentation and can be used to address the cellular and molecular mechanisms that regulate inflammation in the IVD and their implications in tissue degeneration.