Graeme R. Martin

TL;DR: It is evident that in the last decade or so, a vast amount of new information has become available concerning the various 5-HT receptor types and their characteristics, and it is important to rationalise in concert all of the available data from studies involving both operational approaches of the classical pharmacological type and those from molecular and cellular biology.

TL;DR: The reward for unravelling this complex array of serotonin receptor--effector systems may be substantial, the ultimate prize being the development of important new drugs in a range of disease areas.

TL;DR: Based on principles, the present classification of 5-HT1B and 5- HT1D receptors is reconsidered, and a revised nomenclature for 4-HT2D, 4- HT2D alpha and 4-ht2D beta receptor subtypes is suggested.

TL;DR: The current scheme clearly provides a secure and rational basis for classifying and naming 5-HT receptors and the continued efforts of the SRNC are intended to encourage its further evolution towards the ultimate goal of a unitary classification for neurotransmitter/hormone receptors.

TL;DR: In this article, the current data on alternatively spliced variants for hormone and neurotransmitter 7TMs are reviewed, their potential physiological importance considered and some of the issues pertaining to the classification and nomenclature of receptor isoforms produced in this way are addressed.