Showing papers in "Behavioural Brain Research in 1995"

TL;DR: Computer models of self-organization and associative memory function in cortical structures such as the hippocampus, piriform cortex and neocortex provide a theoretical framework in which the role of neuromodulatory effects can be analyzed.

TL;DR: In vitro electrophysiological studies demonstrated that WAY-100635 had no 5-HT1A receptor agonist actions, but dose-dependently blocked the effects of agonists at both the postsynaptic5-HT 1A receptor in the CA1 region of the hippocampus, and the somatodendritic 5-ht1A receptors located on dorsal raphe 5- HT neurones.

TL;DR: The results support the notion that mentally simulated actions in a virtual reality environment are governed by central motor rules.

TL;DR: In animals, there is continuing evidence of relatively small, vulnerable paradoxical sleep windows (PSWs) following successful acquisition, which appear to exhibit shorter latencies to onset when the amount of material presented during acquisition is increased.

TL;DR: Within and outside the brain, multiple pharmacological and behavioral mechanisms contribute to serotonergic functions in ingestion.

TL;DR: The rhythm in melatonin production by the mammalian pineal gland is generated by the circadian timing system, and the components of that system are described.

TL;DR: A hypothesis on the physiological conditions of consciousness is presented and it is assumed that neural assemblies instantiate mental representations; hence consciousness depends on the rate at which large active assemblies are generated.

TL;DR: In addition to modulatory roles concerning bodily functions, sleep is assumed to play a main processing role with regard to newly acquired neural information as mentioned in this paper, which is supported by the results of baseline and post-trial EEG analyses carried out in rats trained for a twoway active avoidance task or a spatial habituation task.

TL;DR: The development of drug taking from controlled intake to drug addiction was studied by means of an animal model and ethanol-addicted rats revealed a completely altered pattern of response to self-administered alcohol compared with controlled drinkers.

TL;DR: Results obtained with the technique demonstrate that selective serotonin reuptake inhibitors are not false negatives in the rat forced swimming test, as previously thought.

TL;DR: It is concluded that microdialysis is at presently the most versatile and practical method to study the chemistry of behaviour and it is to be expected that it will soon be a routine methodology in behavioural research.

TL;DR: It is concluded that serotonergic-cholinergic interactions play an important role in the mediation of behavioural, including cognitive, performance, but that further studies are necessary in order to elucidate the exact nature of these interactions.

TL;DR: It is found that suppression of REM sleep processes by an instrumental REM deprivation procedure results in a significant enhancement of the effects of altered visual experience by monocular occlusion and concludes that REM sleep directs the course of brain maturation in early life through the control of neural activity.

TL;DR: The disk-over-water method permits chronic sleep deprivation of rats with gentle physical stimulation that can be equally applied to yoked control rats, and a series of studies with this method has revealed little or no pathology in the control rats.

TL;DR: The results indicated that rats with the hippocampus removed were impaired on those tasks that require the utilization of spatial and contextual information but performed like controls in learning about and handling (even complex) non-spatial information.

TL;DR: The electrophysiological and thermoregulatory continuum of slow wave sleep, circadian torpor and hibernation substantiates a primordial link between sleep and energy conservation.

TL;DR: Results of electrophysiological and behavioural experiments support the idea that dynamic processes occurring during post-learning PS can contribute to the effectiveness of memory processing and facilitate memory retrieval in wakefulness.

TL;DR: Large amounts of 5-HT are present in the mammalian intestine where the amine is concentrated in the enterochromaffin cells (ECs) of the mucosa, and receptors for vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase stimulating peptide (PACAP) and somatostatin) have been shown to be involved in the control of5-HT release from the ECs.

TL;DR: In this paper, mutant mice lacking the 5-HT1B receptor were generated by homologous recombination, and they exhibited no obvious developmental or behavioral defect, and when confronted with an intruder, isolated mutant mice attacked the intruder faster and more intensely than wild-type mice.

TL;DR: This interactive paradigm views conscious sensation as an active behaviour with the optimal spatial resolution of primary areas serving as the sensory-motor interface at the major convergence point between reentrant bottom-up and top-down pathways.

TL;DR: The evidence for multiple attentional mechanisms is described and links between these neurophysiologically defined mechanisms and specific functional processes that have been proposed in psychological theories of attention are suggested.

TL;DR: A data base from both animal and human clinical research supports the hypothesis of an important cerebellar role in motor adaptation, motor learning and timing, but the evidence for the implication of the cerebellum in psychopathology and non-motor cognitive functions is incomplete and does not allow unequivocal conclusions.

TL;DR: DMT remains unique among classic hallucinogens in its inability to induce tolerance to its psychological effects, suggesting a buffering effect of 5- HT1A agonism on 5-HT2-mediated psychedelic effects.

TL;DR: The results add weight to the view that hippocampal--anterior thalamic connections are critical for normal spatial memory and that the relative contribution of the mamillary bodies is task dependent.

TL;DR: The proposed hypothesis suggests that the cerebellum regulates important features of the cutaneomuscular reflex circuits including the integration of their activity with descending pathways in a manner that implements these fundamental reflex circuits in the organization and control of goal-directed movements of the extremities.

TL;DR: Evidence is reviewed in support of the model that disruption of LI is characteristic of acute, positively-symptomatic schizophrenia and that LI depends upon dopaminergic activity and the integrity of the hippocampal formation and the retrohippocampal region reciprocally connected to the hippocampusal formation.

TL;DR: The research in the field of the brain metabolism during sleep has now come to a turning point, since the confirmation of sizeable cerebral anabolic processes would provide an outstanding argument in favour of the restorative theory of sleep.

TL;DR: The comparison of mammalian species has revealed striking similarities in the way sleep is regulated which indicates common underlying mechanisms.

TL;DR: It is concluded that GR127935 is a useful pharmacological tool to characterise 5-HT1D receptor function and has a good safety profile in all species tested.