Journal ArticleDOI
Classification and nomenclature of 5-HT receptors: a comment on current issues.
Daniel Hoyer,Graeme R. Martin +1 more
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TLDR
The current scheme clearly provides a secure and rational basis for classifying and naming 5-HT receptors and the continued efforts of the SRNC are intended to encourage its further evolution towards the ultimate goal of a unitary classification for neurotransmitter/hormone receptors.About:
This article is published in Behavioural Brain Research.The article was published on 1995-12-15. It has received 145 citations till now.read more
Citations
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Mechanisms involved in the side effects of glucocorticoids
TL;DR: This review summarizes the current knowledge of the most important GC-mediated side effects from a clinical to a molecular perspective and should be helpful in predicting the potential advantages of selective GR agonists in comparison to classical GCs.
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Regulation of Serotonin1A, Glucocorticoid, and Mineralocorticoid Receptor in Rat and Human Hippocampus: Implications for the Neurobiology of Depression
TL;DR: Altered levels in hippocampal 5-HT1A levels and in the MR/GR balance may be one of the mechanisms by which stress may trigger and/or maintain depressive episodes.
Journal ArticleDOI
Molecular biology of 5-HT receptors
Jason P. Hannon,Daniel Hoyer +1 more
TL;DR: Evidence for an even greater degree of operational diversity is supported by the existence of a great number of splice and editing variants for several 5-HT receptors, their possible modulation by accessory proteins and chaperones, as well as their potential to form homo or heteromers both at the GPCR and at the ligand-gated channel level.
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REVIEWS: Pathways of Sexual Desire
TL;DR: Drugs that stimulate the activation of hypothalamic dopamine or that blunt endocannabinoid or serotonin release and/or postsynaptic binding may be effective in stimulating sexual desire in animals and humans.
Journal ArticleDOI
5-HT system and cognition.
TL;DR: Available evidence strongly suggests that the 5-HT system may be important in normal function, the treatment and/or pathogenesis of cognitive disorders, and selective drugs with agonists, neutral antagonist, agonists or inverse agonist properties could constitute a new therapeutic opportunity for learning and memory alterations.
References
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Journal Article
International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).
Daniel Hoyer,David E. Clarke,John R. Fozard,Paul R. Hartig,Graeme R. Martin,Ewan J. Mylecharane,Pramod R. Saxena,Patrick P.A. Humphrey +7 more
TL;DR: It is evident that in the last decade or so, a vast amount of new information has become available concerning the various 5-HT receptor types and their characteristics, and it is important to rationalise in concert all of the available data from studies involving both operational approaches of the classical pharmacological type and those from molecular and cellular biology.
Journal ArticleDOI
A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms.
Timothy W. Lovenberg,Bruce M. Baron,Luis de Lecea,Joseph D. Miller,Rebecca A. Prosser,Michael A. Rea,Pamela E. Foye,Margaret M. Racke,Amy L. Slone,Barry W. Siegel,Patria E. Danielson,J. Gregor Sutcliffe,Mark G. Erlander +12 more
TL;DR: The cloning and characterization of a novel serotonin receptor, designated as 5-HT7, which is coupled to the stimulation of adenylyl cyclase is reported, suggesting a physiological role in the regulation of circadian rhythms for one subtype of serotonin receptor.
Journal Article
Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.
TL;DR: The distinct structural and pharmacological properties of this receptor site indicate that it represents a completely novel subtype of serotonin receptor, and it is likely that this receptor may play a role in several neuropsychiatric disorders that involve serotonergic systems.
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Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (-)[125I]iodocyanopindolol, [3H]mesulergine and [3H]ketanserin.
TL;DR: The pharmacological profile of 5-HT1A sites in rat and pig cortex appears to be identical; 5- HT1C sites in pig choroid plexus and rat cortex show no differences; it was not possible to label 5-ht1B sites with [125I]CYP in pig brain membranes indicating that like 5,HT2 receptors, 5-TT1 recognition sites show species differences.
Journal ArticleDOI
A proposed new nomenclature for 5-HT receptors
TL;DR: The revised 5-HT receptor nomenclature published here was established by the Serotonin Club Receptor NomenClature Committee and approved by IUPHAR.