Graham C. Webb

TL;DR: A new large-animal HD transgenic ovine model selected because the developmental pattern of the ovine basal ganglia and cortex (the regions primarily affected in HD) is similar to the analogous regions of the human brain is developed.

TL;DR: The organization of the mouse Bim gene is investigated, delineating its promoter and splicing, and the gene is positioned on both mouse and human chromosomes to help to clarify the regulation of Bim expression and to assess whether mutations involving Bim contribute to neoplastic and other diseases.

TL;DR: A novel approach to manufacture a DNA microarray for CGH for the detection of aneuploidy in single cells requiring just 30 h is reported, which may be more suitable for PGD aneuPLoidy screening than metaphase CGH.

TL;DR: The glutathione S-transferases (GST) (glutathione transferase; EC 2.5.1.18) are a family of enzymes responsible for the metabolism of a broad range of xenobiotics and carcinogens and indicate that there may be multiple GST-2 genes.

TL;DR: In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyRbeta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1, consistent with the recent finding that a mutation in the murines GlyR Beta subunit causes the spa phenotype.