G
Graham D. Thomas
Researcher at Pfizer
Publications - 25
Citations - 1945
Graham D. Thomas is an academic researcher from Pfizer. The author has contributed to research in topics: CD8 & Monocyte. The author has an hindex of 15, co-authored 24 publications receiving 1410 citations. Previous affiliations of Graham D. Thomas include University of California, San Diego & La Jolla Institute for Allergy and Immunology.
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Journal ArticleDOI
Patrolling monocytes control tumor metastasis to the lung
Richard N. Hanna,Caglar Cekic,Duygu Sag,Robert Tacke,Graham D. Thomas,Heba Nowyhed,Erica Herrley,Nicole Rasquinha,Sara McArdle,Runpei Wu,Esther Peluso,Daniel Metzger,Hiroshi Ichinose,Iftach Shaked,Grzegorz Chodaczek,Subhra K. Biswas,Catherine C. Hedrick +16 more
TL;DR: It is shown that PMo are enriched in the microvasculature of the lung and reduce tumor metastasis to lung in multiple mouse metastatic tumor models and may be targets for cancer immunotherapy.
Journal ArticleDOI
IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1
Stephen J. Jenkins,Dominik Rückerl,Graham D. Thomas,James P. Hewitson,Sheelagh Duncan,Frank Brombacher,Rick M. Maizels,David A. Hume,Judith E. Allen +8 more
TL;DR: IL-4 and CSF-1 both contribute to macrophages proliferation during nematode infection, but IL-4 permits increased tissue macrophage density without the coincident monocyte infiltration associated with elevated CSF1 levels.
Journal ArticleDOI
Nonclassical Patrolling Monocyte Function in the Vasculature
TL;DR: Patrolling monocytes function in several disease settings to remove damaged cells and debris from the vasculature and have been associated with wound healing and the resolution of inflammation in damaged tissues.
Journal ArticleDOI
Human Blood Monocyte Subsets: A New Gating Strategy Defined Using Cell Surface Markers Identified by Mass Cytometry.
Graham D. Thomas,Anouk A.J. Hamers,Catherine Nakao,Paola Marcovecchio,Angela M. Taylor,Chantel McSkimming,Anh T. Nguyen,Coleen A. McNamara,Catherine C. Hedrick +8 more
TL;DR: Using cytometry by time-of-flight mass cytometry, a small panel of surface markers are identified that can significantly improve monocyte subset identification and purity in flow cytometry.
Journal ArticleDOI
Human Monocyte Heterogeneity as Revealed by High-Dimensional Mass Cytometry.
Anouk A.J. Hamers,Huy Q. Dinh,Graham D. Thomas,Paola Marcovecchio,Amy Blatchley,Catherine Nakao,Cheryl Kim,Chantel McSkimming,Angela M. Taylor,Anh T. Nguyen,Coleen A. McNamara,Catherine C. Hedrick +11 more
TL;DR: It is demonstrated that human nonclassical monocytes are a heterogeneous population, existing of several subsets with functional differences in the setting of severe CAD, which is important for CAD-based therapies that target myeloid cells.