P
Paola Marcovecchio
Researcher at La Jolla Institute for Allergy and Immunology
Publications - 22
Citations - 1867
Paola Marcovecchio is an academic researcher from La Jolla Institute for Allergy and Immunology. The author has contributed to research in topics: Monocyte & Antigen. The author has an hindex of 12, co-authored 19 publications receiving 1516 citations. Previous affiliations of Paola Marcovecchio include California Institute of Technology & University of California, San Diego.
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Journal ArticleDOI
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
Florian Klein,Ariel Halper-Stromberg,Joshua A. Horwitz,Henning Gruell,Henning Gruell,Johannes F. Scheid,Johannes F. Scheid,Stylianos Bournazos,Hugo Mouquet,Linda Spatz,Linda Spatz,Ron Diskin,Alexander Abadir,Trinity Zang,Marcus Dorner,Eva Billerbeck,Rachael N. Labitt,Christian Gaebler,Christian Gaebler,Paola Marcovecchio,Reha Baris Incesu,Thomas Eisenreich,Paul D. Bieniasz,Paul D. Bieniasz,Michael S. Seaman,Pamela J. Bjorkman,Jeffrey V. Ravetch,Alexander Ploss,Michel C. Nussenzweig,Michel C. Nussenzweig +29 more
TL;DR: Combinations of potent monoclonal antibodies can effectively control HIV-1 replication in humanized mice, and should be re-examined as a therapeutic modality in HIV- 1-infected individuals.
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Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design
Ron Diskin,Johannes F. Scheid,Johannes F. Scheid,Paola Marcovecchio,Anthony P. West,Florian Klein,Han Gao,Priyanthi N. P. Gnanapragasam,Alexander Abadir,Michael S. Seaman,Michel C. Nussenzweig,Michel C. Nussenzweig,Pamela J. Bjorkman +12 more
TL;DR: Structural analysis of an HIV antibody reveals residues important for neutralization breadth and potency, which indicate that gp120 inner domain and bridging sheet residues should be included in immunogens to elicit CD4bs antibodies.
Journal ArticleDOI
Nonclassical Monocytes in Health and Disease
TL;DR: This review focuses on the state of the monocyte biology field and the functions of monocyte, particularly nonclassical monocytes, in health and disease.
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Identification of an Early Unipotent Neutrophil Progenitor with Pro-tumoral Activity in Mouse and Human Bone Marrow.
Yanfang Peipei Zhu,Lindsey E. Padgett,Huy Q. Dinh,Paola Marcovecchio,Amy Blatchley,Runpei Wu,Erik Ehinger,Cheryl Kim,Zbigniew Mikulski,Grégory Seumois,Ariel Madrigal,Pandurangan Vijayanand,Catherine C. Hedrick +12 more
TL;DR: In this article, the authors used cytometry by time of flight (CyTOF) and single-cell RNA sequencing (scRNA-seq) methodologies to identify a committed unipotent early-stage neutrophil progenitor (NeP) in adult mouse bone marrow.
Journal ArticleDOI
Human Blood Monocyte Subsets: A New Gating Strategy Defined Using Cell Surface Markers Identified by Mass Cytometry.
Graham D. Thomas,Anouk A.J. Hamers,Catherine Nakao,Paola Marcovecchio,Angela M. Taylor,Chantel McSkimming,Anh T. Nguyen,Coleen A. McNamara,Catherine C. Hedrick +8 more
TL;DR: Using cytometry by time-of-flight mass cytometry, a small panel of surface markers are identified that can significantly improve monocyte subset identification and purity in flow cytometry.