G
Graham J. Dockray
Researcher at University of Liverpool
Publications - 326
Citations - 18240
Graham J. Dockray is an academic researcher from University of Liverpool. The author has contributed to research in topics: Gastrin & Cholecystokinin. The author has an hindex of 74, co-authored 326 publications receiving 17805 citations. Previous affiliations of Graham J. Dockray include University of Rome Tor Vergata & Uppsala University.
Papers
More filters
Journal ArticleDOI
Immunochemical evidence of cholecystokinin-like peptides in brain
TL;DR: The present study found the distribution of the brain components on Sephadex G-25 to differ from those of previously characterised forms of gastrin and CCK, suggesting that the brain factors resembled CCK-like peptides more closely than gastrin- like peptides.
Journal ArticleDOI
Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer.
Timothy C. Wang,Charles A. Dangler,Duan Chen,James R. Goldenring,Theodore J. Koh,Raktima Raychowdhury,Robert J. Coffey,Sus Ito,Andrea Varro,Graham J. Dockray,James G. Fox +10 more
TL;DR: Findings support the unexpected conclusion that chronic hypergastrinemia in mice can synergize with Helicobacter infection and contribute to eventual parietal cell loss and progression to gastric cancer.
Journal ArticleDOI
Isolation, structure and biological activity of two cholecystokinin octapeptides from sheep brain
TL;DR: Two octapeptides corresponding to the CCK-like component previously identified by RIA are purified from sheep brain, and the isolation, sequence and some properties of these molecules are reported.
Journal ArticleDOI
The gastrins: their production and biological activities.
TL;DR: The observation that prolonged moderate hypergastrinemia in transgenic mice leads to remodelling of the gastric epithelium, and in the presence of Helicobacter, to gastric cancer is shown.
Journal ArticleDOI
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency
Robert S. Jackson,John W.M. Creemers,I. Sadaf Farooqi,Marie-Laure Raffin-Sanson,Andrea Varro,Graham J. Dockray,Jens J. Holst,Patricia L. Brubaker,Pierre Corvol,Kenneth S. Polonsky,Diane Ostrega,Kenneth L Becker,Xavier Bertagna,John C. Hutton,Anne White,Mehul T. Dattani,Khalid Hussain,Stephen J. Middleton,Thomasina M Nicole,Peter J. Milla,Keith J. Lindley,Stephen O'Rahilly +21 more
TL;DR: It is postulate that PC1, presumably in the enteroendocrine cells, is essential for the normal absorptive function of the human small intestine, and suggests that the precise physiological repertoire of this enzyme may vary between mammalian species.