G
Graham Lappin
Researcher at University of Lincoln
Publications - 56
Citations - 2087
Graham Lappin is an academic researcher from University of Lincoln. The author has contributed to research in topics: Microdosing & Pharmacokinetics. The author has an hindex of 25, co-authored 56 publications receiving 1985 citations. Previous affiliations of Graham Lappin include Covance.
Papers
More filters
Journal ArticleDOI
Big physics, small doses: the use of AMS and PET in human microdosing of development drugs.
Graham Lappin,R. Colin Garner +1 more
TL;DR: A new method of obtaining human metabolism data known as microdosing has been developed which will permit smarter candidate selection by taking investigational drugs into humans earlier, and allows safer human studies as well as reducing the use of animals in preclinical toxicology.
Journal ArticleDOI
Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs
Graham Lappin,Wilhelm Kuhnz,Roeline Jochemsen,Johannes Kneer,Ajai Chaudhary,B. Oosterhuis,Willem Jan Drijfhout,Malcolm Rowland,R. Colin Garner +8 more
TL;DR: A volunteer trial was performed to compare the pharmacokinetics of 5 drugs—warfarin, ZK253 (Schering), diazepam, midazolam, and erythromycin—when administered at a microdose or pharmacologic dose.
Journal ArticleDOI
Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes
James R. Bacon,Gary Williamson,Gary Williamson,R. Colin Garner,Graham Lappin,Sophie Langouët,Yongping Bao +6 more
TL;DR: It is indicated that dietary isothiocyanates and flavonoids modulate phase I and phase II enzyme expression, hence increasing the rate of detoxification of the dietary carcinogen PhIP in human HepG2 cells but do not affect the rates of PhIP-DNA adduct repair.
Journal ArticleDOI
Pharmacokinetics of fexofenadine: evaluation of a microdose and assessment of absolute oral bioavailability.
Graham Lappin,Yoko Shishikura,Roeline Jochemsen,Richard John Weaver,Charlotte Gesson,Brian Houston,B. Oosterhuis,Ole J. Bjerrum,Malcolm Rowland,R. Colin Garner +9 more
TL;DR: Despite a 1200-fold difference in dose of fexofenadine, the microdose predicted well the pharmacokinetic parameters following a therapeutic dose for this transporter dependent compound.
Journal ArticleDOI
The utility of microdosing over the past 5 years.
Graham Lappin,R. Colin Garner +1 more
TL;DR: Of the 18 drugs reported, 15 demonstrated linear pharmacokinetics within a factor of 2 between a microdose and a therapeutic dose, suggesting data that support the utility of microdosing are beginning to emerge.