Greg I. Elmer

TL;DR: The False Discovery Rate (FDR) is the expected proportion of false discoveries among the discoveries, and controlling the FDR goes a long way towards controlling the increased error from multiplicity while losing less in the ability to discover real differences.

TL;DR: It is shown that the metabolism of (R,S)-ketamine to (2S,6S;2R,6R)-hydroxynorketamine (HNK) is essential for its antidepressant effects, and that the HNK enantiomer exerts behavioural, electroencephalographic, electrophysiological and cellular antidepressant-related actions in mice.

TL;DR: This report begins to systematically describe and characterize genetic variability of nociception in a mammalian species, Mus musculus, using 11 readily-available inbred mouse strains and demonstrates the existence of clear strain differences in each assay.

TL;DR: Three major clusters of nociception are revealed: (1) baseline thermal nOCiception, (2) spontaneously-emitted responses to chemical stimuli, and (3) baseline mechanical sensitivity and cutaneous hypersensitivity.

TL;DR: A picture emerges in which a reduction in the astrocytic formation of KYNA increases glutamatergic tone in the hippocampus and enhances cognitive abilities and synaptic plasticity, raising the prospect that interventions aimed at reducing KYNA formation in the brain may constitute a promising molecular strategy for cognitive improvement in health and disease.