G
Greg McMullan
Researcher at Laboratory of Molecular Biology
Publications - 32
Citations - 5037
Greg McMullan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Detective quantum efficiency & Detector. The author has an hindex of 21, co-authored 31 publications receiving 4070 citations. Previous affiliations of Greg McMullan include University of Cambridge.
Papers
More filters
Journal ArticleDOI
High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy.
Shaoxia Chen,Greg McMullan,A.R. Faruqi,Garib N. Murshudov,Judith M. Short,Sjors H.W. Scheres,Richard Henderson +6 more
TL;DR: Applying this procedure to cryoEM images of beta-galactosidase shows how overfitting varies greatly depending on the procedure, but in the best case shows no overfitting and a resolution of ~6 Å.
Journal ArticleDOI
How cryo-EM is revolutionizing structural biology
TL;DR: The recent advances in electron detection and image processing are reviewed and the exciting new opportunities that they offer to structural biology research are illustrated.
Journal ArticleDOI
A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes
Antonis C. Antoniou,Paul D.P. Pharoah,Greg McMullan,Nicholas E. Day,Michael R. Stratton,Julian Peto,Bruce A.J. Ponder,Doug Easton +7 more
TL;DR: The findings suggest that several common, low penetrance genes with multiplicative effects on risk may account for the residual non-BRCA1/2 familial aggregation of breast cancer.
Journal ArticleDOI
Single-particle cryo-EM at atomic resolution.
Takanori Nakane,Abhay Kotecha,Andrija Sente,Greg McMullan,S. Masiulis,S. Masiulis,Patricia M. G. E. Brown,Ioana T. Grigoras,Ioana T. Grigoras,Lina Malinauskaite,Tomas Malinauskas,Jonas Miehling,Tomasz Uchański,Lingbo Yu,D. Karia,Evgeniya V. Pechnikova,Erwin de Jong,Jeroen Keizer,Maarten Bischoff,Jamie McCormack,Peter Tiemeijer,Steven W. Hardwick,Dimitri Y. Chirgadze,Garib N. Murshudov,A. Radu Aricescu,Sjors H.W. Scheres +25 more
TL;DR: A new electron source, energy filter and camera are used to obtain a 1.7 Å resolution cryo-EM reconstruction for a human membrane protein, the β3 GABA A receptor homopentamer, allowing a detailed understanding of small-molecule coordination, visualization of solvent molecules and alternative conformations for multiple amino acids, and unambiguous building of ordered acidic side chains and glycans.
Journal ArticleDOI
Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles
TL;DR: It is shown that ribosome reconstructions with unprecedented resolutions may be calculated from almost two orders of magnitude fewer particles than used previously, which may expand the scope of high-resolution cryo-EM to a broad range of biological specimens.