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A.R. Faruqi
Researcher at Laboratory of Molecular Biology
Publications - 51
Citations - 3253
A.R. Faruqi is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Detector & Image resolution. The author has an hindex of 23, co-authored 51 publications receiving 2980 citations. Previous affiliations of A.R. Faruqi include Medical Research Council.
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Journal ArticleDOI
High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy.
Shaoxia Chen,Greg McMullan,A.R. Faruqi,Garib N. Murshudov,Judith M. Short,Sjors H.W. Scheres,Richard Henderson +6 more
TL;DR: Applying this procedure to cryoEM images of beta-galactosidase shows how overfitting varies greatly depending on the procedure, but in the best case shows no overfitting and a resolution of ~6 Å.
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Structural changes during activation of frog muscle studied by time-resolved X-ray diffraction.
TL;DR: Tropomyosin movement, in response to calcium binding to troponin, is the first structural step in muscular contraction, and is the prerequisite for myosin binding.
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Protein conformational changes in the bacteriorhodopsin photocycle.
Sriram Subramaniam,Martin Lindahl,Per A. Bullough,A.R. Faruqi,Jörg Tittor,Dieter Oesterhelt,Leonid S. Brown,Janos K. Lanyi,Richard Henderson +8 more
TL;DR: It is proposed that in wild-type bacteriorhodopsin and in most mutants, this conformational change between the M1 and M2 states is likely to make an important contribution towards efficiently switching proton accessibility of the Schiff base from the extracellular side to the cytoplasmic side of the membrane.
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Time-resolved X-ray diffraction studies of the myosin layer-line reflections during muscle contraction
TL;DR: It is found that, with rare exceptions, freshly dissected muscles always show a substantial increase in the integrated intensity of the 143 A meridional reflection during the peak of both tetani and twitches, which indicates a close correlation between the helical disordering of crossbridges and tension development.
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Changes in the X-ray reflections from contracting muscle during rapid mechanical transients and their structural implications.
TL;DR: A model is suggested in which the 143 A meridional intensity in a contracting muscle arises mainly from attached cross-bridges and is generated by the part of the myosin head near the S1-S2 junction.