G
Grey P. Madison
Researcher at National Institutes of Health
Publications - 4
Citations - 186
Grey P. Madison is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Mitochondrion & Mitochondrial fission. The author has an hindex of 2, co-authored 4 publications receiving 138 citations.
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Journal ArticleDOI
Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse.
Sricharan Murugesan,Jinsung Hong,Jason Yi,Dong Li,Dong Li,Jordan R. Beach,Lin Shao,John Meinhardt,Grey P. Madison,Xufeng Wu,Eric Betzig,John A. Hammer +11 more
TL;DR: The authors reveal the origin, organization, and functions of a major cytoskeletal network during synapse maturation and report that actomyosin arcs at the T cell synapse are formin-generated structures that directly propel T cell receptor cluster movement.
Journal ArticleDOI
Mitochondrial DNA segregation and replication restrict the transmission of detrimental mutation
Zhe Chen,Zong-Heng Wang,Guofeng Zhang,Christopher K. E. Bleck,Dillon J. Chung,Grey P. Madison,Eric Lindberg,Christian A. Combs,Robert S. Balaban,Hong Xu +9 more
TL;DR: It is demonstrated that a series of developmentally orchestrated mitochondrial processes in the Drosophila early germarium allow the functional manifestation of individual genomes and contribute to a selective inheritance, limiting the transmission of detrimental mtDNA mutations.
Posted ContentDOI
Metabolic design in a model of extreme mammalian metabolism, the North American least shrew (Cryptotis parva)
Dillon J. Chung,Grey P. Madison,Angel Aponte,Komudi Singh,Yuesheng Li,Mehdi Pirooznia,Christopher K. E. Bleck,Nissar A. Darmani,Robert S. Balaban +8 more
TL;DR: In this paper, the authors investigated organ-specific mitochondrial morphology, connectivity and protein composition in a model of extreme mammalian metabolism, the Least shrew (Cryptotis parva), using a combination of high-resolution 3D focused-ion-beam EM imaging and tandem-mass-tag MS proteomics.
Posted ContentDOI
Developmentally-orchestrated mitochondrial processes prime the selection against harmful mtDNA mutations
Zhe Chen,Zong-Heng Wang,Guofeng Zhang,Bleck Cke,Dillon J. Chung,Grey P. Madison,Eric Lindberg,Christian A. Combs,Robert S. Balaban,Huichun Xu +9 more
TL;DR: In this paper, the authors used Drosophila to dissect the mechanisms of mtDNA selective inheritance and understand their molecular underpinnings, showing that mtDNA fission and lack of mt DNA replication in early germarium effectively segregates mtDNA into individual organelles.