S
Sricharan Murugesan
Researcher at National Institutes of Health
Publications - 5
Citations - 298
Sricharan Murugesan is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Immunological synapse & T-cell receptor. The author has an hindex of 4, co-authored 5 publications receiving 243 citations. Previous affiliations of Sricharan Murugesan include Cornell University.
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Journal ArticleDOI
Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse.
Sricharan Murugesan,Jinsung Hong,Jason Yi,Dong Li,Dong Li,Jordan R. Beach,Lin Shao,John Meinhardt,Grey P. Madison,Xufeng Wu,Eric Betzig,John A. Hammer +11 more
TL;DR: The authors reveal the origin, organization, and functions of a major cytoskeletal network during synapse maturation and report that actomyosin arcs at the T cell synapse are formin-generated structures that directly propel T cell receptor cluster movement.
Journal ArticleDOI
Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes.
Alex T. Ritter,Alex T. Ritter,Senta M. Kapnick,Sricharan Murugesan,Pamela L. Schwartzberg,Gillian M. Griffiths,Jennifer Lippincott-Schwartz +6 more
TL;DR: It is demonstrated here that dynamic regulation of the cortical actin cytoskeleton is critical for both the initiation and termination of secretion, providing insight into actin-related mechanisms regulating CTL secretion that may facilitate serial killing during immune responses.
Journal ArticleDOI
Identification of Diverse Lipid Droplet Targeting Motifs in the PNPLA Family of Triglyceride Lipases
TL;DR: Results show that even closely related members of the PNPLA family employ different molecular motifs to associate with LDs, including two different types of LTMs in ATGL and Brummer Lipase.
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Contractile actomyosin arcs promote the activation of primary mouse T cells in a ligand-dependent manner.
TL;DR: The ligand-dependent contribution made by contractile actomyosin arcs populating the peripheral supramolecular activation cluster (pSMAC) region of the immunological synapse (IS) to T cell receptor (TCR) microcluster transport and proximal signaling in primary mouse T cells is investigated.