C
Christian A. Combs
Researcher at National Institutes of Health
Publications - 65
Citations - 5508
Christian A. Combs is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Mitochondrion & Skeletal muscle. The author has an hindex of 27, co-authored 61 publications receiving 4706 citations. Previous affiliations of Christian A. Combs include Office of Technology Transfer.
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Journal ArticleDOI
Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma
Aarif Y. Khakoo,Aarif Y. Khakoo,Shibani Pati,Stasia A. Anderson,William Reid,Mohamed F. Elshal,Ilsa I Rovira,Ahn T Q Nguyen,Daniela Malide,Christian A. Combs,Gentzon Hall,Jianhu Zhang,Mark Raffeld,Terry B. Rogers,William G. Stetler-Stevenson,Joseph A. Frank,Marvin S. Reitz,Toren Finkel +17 more
TL;DR: The results suggest that in contrast to other stem cells or normal stromal cells, MSCs possess intrinsic antineoplastic properties and that this stem cell population might be of particular utility for treating those human malignancies characterized by dysregulated Akt.
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Measuring In Vivo Mitophagy
Nuo Sun,Jeanho Yun,Jie Liu,Daniela Malide,Chengyu Liu,Ilsa I. Rovira,Kira M. Holmström,Maria M. Fergusson,Young Hyun Yoo,Christian A. Combs,Toren Finkel +10 more
TL;DR: A transgenic mouse model in which a mitochondrial-targeted form of the fluorescent reporter Keima was expressed, a coral-derived protein that exhibits both pH-dependent excitation and resistance to lysosomal proteases, is described, suggesting that the mt-Keima mouse should be a valuable resource.
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Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells.
Kathleen A. Hinds,Jonathan Hill,Erik M. Shapiro,Mikko O. Laukkanen,Alfonso C. Silva,Christian A. Combs,Timothy R. Varney,Robert S. Balaban,Alan P. Koretsky,Cynthia E. Dunbar +9 more
TL;DR: A new application of much larger, micron-scale, iron oxide magnetic particles with enhanced MR susceptibility, which enables detection of single cells at resolutions that can be achieved in vivo, appears to be a promising tool for serial noninvasive monitoring of in vivo cell homing and localization using MRI.
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Resolution doubling in live, multicellular organisms via multifocal structured illumination microscopy
Andrew York,Sapun H. Parekh,Sapun H. Parekh,Damian Dalle Nogare,Robert S. Fischer,Kelsey Temprine,Marina Mione,Ajay B. Chitnis,Christian A. Combs,Hari Shroff +9 more
TL;DR: Sparse multifocal illumination patterns generated by a digital micromirror device allowed us to physically reject out-of-focus light, enabling 3D subdiffractive imaging in samples eightfold thicker than had been previously imaged with SIM.
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Mitochondrial reticulum for cellular energy distribution in muscle
Brian Glancy,Lisa M. Hartnell,Daniela Malide,Zu Xi Yu,Christian A. Combs,Patricia S. Connelly,Sriram Subramaniam,Robert S. Balaban +7 more
TL;DR: A mitochondrial reticulum providing a conductive pathway for energy distribution, in the form of the proton-motive force, throughout the mouse skeletal muscle cell is demonstrated and it is proposed that membrane potential conduction via the mitochondrial Reticulum is the dominant pathway for skeletal muscle energy distribution.