G
Gualtiero Mariani
Researcher at Istituto Superiore di Sanità
Publications - 53
Citations - 2343
Gualtiero Mariani is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Haematopoiesis & Cellular differentiation. The author has an hindex of 26, co-authored 53 publications receiving 2217 citations. Previous affiliations of Gualtiero Mariani include Thomas Jefferson University & Sapienza University of Rome.
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Journal ArticleDOI
Elevated expression of IL-3Rα in acute myelogenous leukemia is associated with enhanced blast proliferation, increased cellularity, and poor prognosis
Ugo Testa,Ugo Testa,Ugo Testa,Roberta Riccioni,Roberta Riccioni,Roberta Riccioni,Stefania Militi,Stefania Militi,Stefania Militi,Eliana Marina Coccia,Eliana Marina Coccia,Eliana Marina Coccia,Emilia Stellacci,Emilia Stellacci,Emilia Stellacci,Paola Samoggia,Paola Samoggia,Paola Samoggia,Roberto Latagliata,Roberto Latagliata,Roberto Latagliata,Gualtiero Mariani,Gualtiero Mariani,Gualtiero Mariani,Annalisa Rossini,Annalisa Rossini,Annalisa Rossini,Angela Battistini,Angela Battistini,Angela Battistini,Francesco Lo-Coco,Francesco Lo-Coco,Francesco Lo-Coco,Cesare Peschle,Cesare Peschle,Cesare Peschle +35 more
TL;DR: Findings suggest that in AML, deregulated expression of IL-3Ralpha may contribute to the proliferative advantage of the leukemic blasts and, hence, to a poor prognosis.
Journal ArticleDOI
Transferrin receptor 2 is frequently expressed in human cancer cell lines.
Alessia Calzolari,Isabella Oliviero,Silvia Deaglio,Gualtiero Mariani,Mauro Biffoni,Nadia Maria Sposi,Fabio Malavasi,Cesare Peschle,Ugo Testa +8 more
TL;DR: Experiments of in vitro iron loading or iron deprivation provided evidence that TfR2 is modulated in cancer cell lines according to cellular iron levels following two different mechanisms: (i) in some cells, iron loading caused a downmodulation of total T fR2 levels; (ii) in other cell types, iron loaders caused aDownmodulations of membrane-bound TFR2, without affecting the levels of total cellular Tf R2 content.
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Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors.
Nadia Maria Sposi,Leonard I. Zon,Alessandra Carè,Mauro Valtieri,Ugo Testa,Marco Gabbianelli,Gualtiero Mariani,Lisabianca Bottero,Cheri Mather,Stuart H. Orkin +9 more
TL;DR: A microenvironment-directed, two-step model for GATA-1 expression in differentiating hematopoietic progenitors that involves (i) cycle-dependent initiation and (ii) lineage-dependent maintenance or suppression is suggested.
Journal ArticleDOI
TRAIL decoy receptors mediate resistance of acute myeloid leukemia cells to TRAIL.
Roberta Riccioni,Luca Pasquini,Gualtiero Mariani,Ernestina Saulle,Annalisa Rossini,Daniela Diverio,Elvira Pelosi,Antonella Vitale,Anna Chierichini,Michele Cedrone,Robin Foà,Francesco Lo Coco,Cesare Peschle,Ugo Testa +13 more
TL;DR: It is suggested that acute myeloblastic leukemias, including APL blasts, are resistant to TRAIL-mediated apoptosis, a phenomenon seemingly related to the expression of TRAIL decoy receptors on these cells.
Journal ArticleDOI
Expression of growth factor receptors in unilineage differentiation culture of purified hematopoietic progenitors
Ugo Testa,C Fossati,Paola Samoggia,Rosalba Masciulli,Gualtiero Mariani,Hamisa Jane Hassan,Nadia Maria Sposi,R Guerriero,V Rosato,Marco Gabbianelli,Elvira Pelosi,Mauro Valtieri,Cesare Peschle +12 more
TL;DR: Evaluated growth factor receptors exhibit a gradual induction followed by a sustained expression in the E, G, MK, and Mo lineages, respectively, and are compatible with the following multi-step model.