R
R Guerriero
Researcher at Istituto Superiore di Sanità
Publications - 29
Citations - 1154
R Guerriero is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Haematopoiesis & Cellular differentiation. The author has an hindex of 16, co-authored 29 publications receiving 1102 citations. Previous affiliations of R Guerriero include Thomas Jefferson University.
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Journal ArticleDOI
Haemoglobin switching in human embryos: asynchrony of ζ → α and ε → γ-globin switches in primitive and definitive erythropoietic lineage
Cesare Peschle,Fulvio Mavilio,Alessandra Carè,Giovanni Migliaccio,Anna Rita Migliaccio,G. Salvo,Paola Samoggia,S Petti,R Guerriero,Marino Marinucci,Damiana Lazzaro,Giuseppe Russo,G. Mastroberardino +12 more
TL;DR: The embryonic→fetal haemoglobin switches in yolk sac, liver and circulating blood erythroblasts from 25 embryos and 6 fetuses are studied in terms of a monoclonal model forHaemoglobin switching in early human ontogeny.
Journal ArticleDOI
Autocrine-paracrine VEGF loops potentiate the maturation of megakaryocytic precursors through Flt1 receptor.
Ida Casella,Tiziana Feccia,Tiziana Feccia,C Chelucci,C Chelucci,Paola Samoggia,Paola Samoggia,Germana Castelli,Germana Castelli,R Guerriero,R Guerriero,Isabella Parolini,Isabella Parolini,Eleonora Petrucci,Eleonora Petrucci,Elvira Pelosi,Elvira Pelosi,Ornella Morsilli,Ornella Morsilli,Marco Gabbianelli,Marco Gabbianelli,Ugo Testa,Ugo Testa,Cesare Peschle,Cesare Peschle +24 more
TL;DR: The results suggest that in the hematopoietic microenvironment an autocrine VEGF loop contributes to optimal Mk maturation through Flt1 and a paracrine loop involving V EGF release by E precursors may also operate.
Journal ArticleDOI
Unilineage megakaryocytic proliferation and differentiation of purified hematopoietic progenitors in serum-free liquid culture.
R Guerriero,Ugo Testa,Marco Gabbianelli,Gianfranco Mattia,E. Montesoro,Giampiero Macioce,A. Pace,Benedikt L. Ziegler,Hamisa Jane Hassan,Cesare Peschle +9 more
TL;DR: The purified peripheral blood HPC differentiation culture system allows for growth of a relatively large number of highly purified or "pure" megakaryocytic precursors and then mature MKs, thus providing an in vitro experimental tool to dissect the cellular and molecular basis of megakARYocytopoiesis.
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Expression of growth factor receptors in unilineage differentiation culture of purified hematopoietic progenitors
Ugo Testa,C Fossati,Paola Samoggia,Rosalba Masciulli,Gualtiero Mariani,Hamisa Jane Hassan,Nadia Maria Sposi,R Guerriero,V Rosato,Marco Gabbianelli,Elvira Pelosi,Mauro Valtieri,Cesare Peschle +12 more
TL;DR: Evaluated growth factor receptors exhibit a gradual induction followed by a sustained expression in the E, G, MK, and Mo lineages, respectively, and are compatible with the following multi-step model.
Journal ArticleDOI
Aspirin extrusion from human platelets through multidrug resistance protein-4-mediated transport: evidence of a reduced drug action in patients after coronary artery bypass grafting.
Teresa Mattiello,R Guerriero,Lavinia Vittoria Lotti,Elisabetta Trifirò,Maria Pia Felli,Alessandro Barbarulo,Bruna Pucci,Paola Gazzaniga,Carlo Gaudio,Luigi Frati,Fabio M. Pulcinelli +10 more
TL;DR: In this paper, the role of multidrug resistance protein-4 (MRP4), an organic anion unidirectional transporter, in modulating aspirin action on human platelet cyclooxygenase (COX)-1 was investigated.