M
Marco Gabbianelli
Researcher at Istituto Superiore di Sanità
Publications - 66
Citations - 3346
Marco Gabbianelli is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Haematopoiesis & Cellular differentiation. The author has an hindex of 30, co-authored 63 publications receiving 3248 citations. Previous affiliations of Marco Gabbianelli include Thomas Jefferson University & Wistar Institute.
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Journal ArticleDOI
KDR receptor: a key marker defining hematopoietic stem cells.
Benedikt L. Ziegler,Mauro Valtieri,Mauro Valtieri,G. Almeida Porada,R De Maria,R De Maria,Robert Müller,B. Masella,Marco Gabbianelli,Ida Casella,Elvira Pelosi,T. Bock,Esmail D. Zanjani,Cesare Peschle,Cesare Peschle +14 more
TL;DR: KDR is a positive functional marker defining stem cells and distinguishing them from progenitors, comparable to the CD34 marker of hematopoietic progenitor cells.
Journal ArticleDOI
Identification of the hemangioblast in postnatal life.
Elvira Pelosi,Mauro Valtieri,Simona Coppola,Rosanna Botta,Marco Gabbianelli,Valentina Lulli,Giovanna Marziali,Barbara Masella,Robert Müller,Cecilia Sgadari,Ugo Testa,Giuseppina Bonanno,Cesare Peschle +12 more
TL;DR: These studies identified postnatal hemangioblasts in a CD34(+)KDR(+) cell subset, endowed with long-term proliferative potential and bilineage differentiation capacity.
Journal ArticleDOI
"Pure" human hematopoietic progenitors: permissive action of basic fibroblast growth factor.
TL;DR: A regulatory role for basic fibroblast growth factor is suggested in early hematopoiesis, which requires not only the stimulatory effect of interleukin-3, granulocyte-macrophage colony-stimulating factor, and erythropoietin, but also the permissive action of basic fibronectin.
Journal ArticleDOI
Multi-Level Effects of flt3 Ligand on Human Hematopoiesis: Expansion of Putative Stem Cells and Proliferation of Granulomonocytic Progenitors/Monocytic Precursors
Marco Gabbianelli,Elvira Pelosi,E. Montesoro,Mauro Valtieri,Luisella Luchetti,Paola Samoggia,Luigi Vitelli,T. Barberi,Ugo Testa,S. D. Lyman +9 more
TL;DR: The results indicate that FL exerts a stimulatory action on primitive HPCs, including a unique expanding effect on putative stem cells, whereas its distal proliferative/differentiative action is largely restricted to CFU-GM and monocytic precursors.
Journal ArticleDOI
Autocrine-paracrine VEGF loops potentiate the maturation of megakaryocytic precursors through Flt1 receptor.
Ida Casella,Tiziana Feccia,Tiziana Feccia,C Chelucci,C Chelucci,Paola Samoggia,Paola Samoggia,Germana Castelli,Germana Castelli,R Guerriero,R Guerriero,Isabella Parolini,Isabella Parolini,Eleonora Petrucci,Eleonora Petrucci,Elvira Pelosi,Elvira Pelosi,Ornella Morsilli,Ornella Morsilli,Marco Gabbianelli,Marco Gabbianelli,Ugo Testa,Ugo Testa,Cesare Peschle,Cesare Peschle +24 more
TL;DR: The results suggest that in the hematopoietic microenvironment an autocrine VEGF loop contributes to optimal Mk maturation through Flt1 and a paracrine loop involving V EGF release by E precursors may also operate.