Guan-Qun Zhou

TL;DR: Induction chemotherapy added to chemoradiotherapy significantly improved recurrence-free survival and overall survival, as compared with chemoradaotherapy alone, among patients with locoregionally advanced nasopharyngeal carcinoma.

TL;DR: A potential ceRNA regulatory pathway in which FAM225A modulates ITGB3 expression by binding to miR-590-3p and miR -1275, ultimately promoting tumorigenesis and metastasis in NPC is revealed.

TL;DR: This work generated single-cell transcriptome profiles for 7581 malignant cells and 40,285 immune cells from fifteen primary NPC tumors and one normal sample and established the immune subtype-specific signatures, demonstrating that the signatures of macrophages, plasmacytoid dendritic cells (pDCs), CLEC9A+ DCs, natural killer cells, and plasma cells were significantly associated with improved survival outcomes in NPC.

TL;DR: IRGPI is a promising biomarker to distinguish the prognosis, the molecular and immune characteristics, and the immune benefit from ICI therapy in HNSCC.

TL;DR: The authors show the prognostic value of monitoring the level of circulating Epstein-barr virus DNA throughout induction chemotherapy and chemo-radiotherapy and its potential utility for risk-adapted individualised therapy in nasopharyngeal carcinomapatients.