Michael Dean

TL;DR: A comprehensive picture of the HCC ecosystem provides deeper insights into immune evasion mechanisms associated with tumor relapse, including those that dampen DC antigen presentation and recruit innate-like CD8+ T cells.

TL;DR: This work generated single-cell transcriptome profiles for 7581 malignant cells and 40,285 immune cells from fifteen primary NPC tumors and one normal sample and established the immune subtype-specific signatures, demonstrating that the signatures of macrophages, plasmacytoid dendritic cells (pDCs), CLEC9A+ DCs, natural killer cells, and plasma cells were significantly associated with improved survival outcomes in NPC.

TL;DR: About one-fourth of patients with osteosarcoma unselected for family history had a highly penetrant germline mutation requiring additional follow-up analysis and possible genetic counseling with cascade testing.

TL;DR: The results further support the conclusion that Delta32-mediated resistance is incomplete and is associated with acquisition of exclusively-X4 variants of HIV-1.

TL;DR: CCR5-Delta 32/Delta 32 homozygosity does not provide broad protection against viral infections, and the prevalence of antibodies to nine other common viruses, HBV, and HCV was not related to CCR5 genotype.