G
Guang-Biao Zhou
Researcher at Peking Union Medical College
Publications - 132
Citations - 6815
Guang-Biao Zhou is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 36, co-authored 121 publications receiving 5607 citations. Previous affiliations of Guang-Biao Zhou include Chinese Academy of Sciences & Lanzhou University.
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Journal ArticleDOI
A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo.
Suping Li,Qiao Jiang,Shaoli Liu,Yinlong Zhang,Yanhua Tian,Yanhua Tian,Chen Song,Jing Wang,Yiguo Zou,Gregory J. Anderson,Jing Yan Han,Yung Chang,Yan Liu,Chen Zhang,Liang Chen,Guang-Biao Zhou,Guangjun Nie,Guangjun Nie,Hao Yan,Baoquan Ding,Yuliang Zhao,Yuliang Zhao +21 more
TL;DR: It is demonstrated that intravenously injected DNA nanorobots deliver thrombin specifically to tumor-associated blood vessels and induce intravascular thrombosis, resulting in tumor necrosis and inhibition of tumor growth.
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Arsenic Trioxide Controls the Fate of the PML-RARα Oncoprotein by Directly Binding PML
Xiaowei Zhang,Xiaojing Yan,Zi-Ren Zhou,Feifei Yang,Ziyu Wu,Hongbin Sun,Wen-Xue Liang,Ai-Xin Song,Valérie Lallemand-Breitenbach,Marion Jeanne,Qun-Ye Zhang,Huai-Yu Yang,Qiu-Hua Huang,Guang-Biao Zhou,Jian-Hua Tong,Yan Zhang,Jihui Wu,Hong-Yu Hu,Sai Juan Chen,Zhu Chen +19 more
TL;DR: It is shown that arsenic binds directly to cysteine residues in zinc fingers located within the RBCC domain of PML-RARα and PML, identifying PML as a direct target of As2O3 and providing new insights into the drug’s mechanism of action and its specificity for APL.
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Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia
Lan Wang,Guang-Biao Zhou,Guang-Biao Zhou,Ping Liu,Jun Hong Song,Yang Liang,Xiao Jing Yan,Fang Xu,Bing-Shun Wang,Jian-Hua Mao,Zhi Xiang Shen,Sai Juan Chen,Zhu Chen +12 more
TL;DR: ITA causes intensified ubiquitination/degradation of promyelocytic leukemia (PML)-retinoic acid receptor α (RARα) oncoprotein, stronger reprogramming of myeloid differentiation regulators, and enhanced G1/G0 arrest in APL cells through hitting multiple targets compared with the effects of mono- or biagents.
Journal ArticleDOI
Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia
Jiong Hu,Yuan Fang Liu,Chuanfeng Wu,Fang Xu,Zhi Xiang Shen,Yong Mei Zhu,J. Li,Wei Tang,Zhao Wl,Wen Wu,Hui Ping Sun,Qiu Sheng Chen,Bing Chen,Guang-Biao Zhou,Guang-Biao Zhou,Arthur Zelent,Samuel Waxman,Zhen Yi Wang,Sai Juan Chen,Zhu Chen +19 more
TL;DR: The results demonstrate the high efficacy and minimal toxicity of ATRA/ATO treatment for newly diagnosed APL in long-term follow-up, suggesting a potential frontline therapy for de novo APL.
Journal ArticleDOI
AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: Implication in stepwise leukemogenesis and response to Gleevec
Yue-Ying Wang,Guang-Biao Zhou,Tong Yin,Bing Chen,Jing-Yi Shi,Wen-Xue Liang,Xiao-Long Jin,Jian-Hua You,Guang Yang,Zhi-Xiang Shen,Jue Chen,Shu-Min Xiong,Guo-Qiang Chen,Feng Xu,Yi-Wei Liu,Zhu Chen,Sai-Juan Chen +16 more
TL;DR: The data strongly suggest that t(8;21) AML follows a stepwise model in leukemogenesis, i.e., AE represents the first, fundamental genetic hit to initiate the disease, whereas activation of the C-KIT pathway may be a second but also crucial hit for the development of a full-blown leukemia.