Guido Tarone

TL;DR: Analysis of intracellular signaling events induced by pressure overload indicated that phosphorylation of glycogen synthase kinase-3 β (GSK-3β) was specifically blunted in melusin-null hearts, which prevents cardiac dilation during chronic pressure overload by specifically sensing mechanical stress.

TL;DR: Although not necessary for signaling to ERK in primary fibroblasts, FAK may enhance and prolong integrin-mediated activation of ERK through p130CAS, Crk, and Rap1 in cells expressing B-Raf.

TL;DR: It is shown that integrin-induced signalling pathways are necessary for EGF-dependent transcriptional response, demonstrating the requirement of the co-operation between cell-matrix adhesion and EGFR to achieve full biological responses.

TL;DR: It is shown that actin stress fiber and focal adhesion formation following adhesion requires cooperation between integrin‐mediated signaling and additional stimuli, including activation of PKC, Rho GTPases, and PTKs such as p125Fak and Src.

TL;DR: It is reported that the integrin complex alpha 1/beta 1, a laminin/collagen receptor, is expressed on cultured foreskin microvascular endothelium, but is absent on endothelial cells from large vessels such as the aorta and umbilical and femoral veins.