Emilia Turco

TL;DR: It is shown that mouse mutants expressing a catalytically inactive PIK3CBK805R mutant survived to adulthood but showed growth retardation and developed mild insulin resistance with age, indicating an unexpected role for p110β catalytic activity in diabetes and cancer, opening potential avenues for therapeutic intervention.

TL;DR: The results indicate that Citron-K is essential for cytokinesis in vivo but only in specific neuronal precursors, and suggest a novel molecular mechanism for a subset of human malformative syndromes of the CNS.

TL;DR: This finding suggests that heme controls a macrophage iron recycling regulon involving Btb and Cnc Homology 1 and Nuclear Factor Erythroid 2-like to assure the coordinated degradation of heme by heme oxygenase 1, iron storage and detoxification by ferritin, and iron export by iron export protein ferroportin.

TL;DR: Surprisingly, inhibition of eNOS prevents Ubiad1-dependent cardiovascular oxidative damage, suggesting a crucial role for this enzyme and nonmitochondrial CoQ10 in NO signaling.

TL;DR: It is shown that integrin-induced signalling pathways are necessary for EGF-dependent transcriptional response, demonstrating the requirement of the co-operation between cell-matrix adhesion and EGFR to achieve full biological responses.