G
Guillaume Witz
Researcher at University of Bern
Publications - 30
Citations - 1363
Guillaume Witz is an academic researcher from University of Bern. The author has contributed to research in topics: DNA supercoil & DNA. The author has an hindex of 16, co-authored 28 publications receiving 1183 citations. Previous affiliations of Guillaume Witz include Swiss Institute of Bioinformatics & University of Lausanne.
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Journal ArticleDOI
Four-Dimensional Imaging of E. coli Nucleoid Organization and Dynamics in Living Cells
TL;DR: The presented results suggest a general conceptual framework for bacterial nucleoid morphogenesis and dynamics, implying cyclic accumulation and relief of intranucleoid mechanical stress in a chromosome-based cell-cycle engine.
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Fractal dimension and localization of DNA knots
Erika Ercolini,Francesco Valle,Jozef Adamcik,Guillaume Witz,Ralf Metzler,Paolo De Los Rios,Joaquim Roca,Giovanni Dietler +7 more
TL;DR: The scaling properties of DNA knots of different complexities were studied by atomic force microscope and evidence is presented for the localization of knot crossings in 2D under weak adsorption conditions.
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Chromosomes Progress to Metaphase in Multiple Discrete Steps via Global Compaction/Expansion Cycles
Zhangyi Liang,Denise Zickler,Mara Prentiss,Frederick S. Chang,Guillaume Witz,Kazuhiro Maeshima,Nancy Kleckner +6 more
TL;DR: In this paper, a 4D live-cell and snapshot deconvolution fluorescence imaging was used to analyze mitotic chromosome morphogenesis, showing that chromosomes expand, axes split and straighten, and chromatin loops transit to a radial disposition around now-central axes.
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Observation of single-stranded DNA on mica and highly oriented pyrolytic graphite by atomic force microscopy
TL;DR: It is shown that the immobilization of ssDNA under standard conditions on modified HOPG eliminates intramolecular base‐pairing, thus this method could be important for studying certain processes involving ssDNA in more details.
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DNA supercoiling and its role in DNA decatenation and unknotting
Guillaume Witz,Andrzej Stasiak +1 more
TL;DR: The role of DNA supercoiling is overviewed and consists of aiding DNA topoisomerases in DNA decatenation and unknotting, which aids such processes as DNA replication or transcription that require global- or local-strand separation.