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Guixia Liu
Researcher at East China University of Science and Technology
Publications - 189
Citations - 7103
Guixia Liu is an academic researcher from East China University of Science and Technology. The author has contributed to research in topics: Medicine & Computer science. The author has an hindex of 34, co-authored 156 publications receiving 4954 citations. Previous affiliations of Guixia Liu include Chinese Academy of Sciences & East China Normal University.
Papers
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Journal ArticleDOI
Classification of cytochrome P450 inhibitors and noninhibitors using combined classifiers.
Feixiong Cheng,Yue Yu,Jie Shen,Lei Yang,Weihua Li,Guixia Liu,Philip W. Lee,Philip W. Lee,Yun Tang +8 more
TL;DR: These classification models are applicable for virtual screening of the five major CYP isoforms inhibitors or can be used as simple filters of potential chemicals in drug discovery.
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In Silico Prediction of Chemical Toxicity for Drug Design Using Machine Learning Methods and Structural Alerts.
TL;DR: This research presents a novel probabilistic procedure called “spot-spot analysis” that allows for real-time analysis of the response of the immune system to Epstein-Barr virus.
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In silico Prediction of Chemical Ames Mutagenicity
Congying Xu,Feixiong Cheng,Lei Chen,Zheng Du,Weihua Li,Guixia Liu,Guixia Liu,Philip W. Lee,Yun Tang +8 more
TL;DR: A comprehensive database containing 7617 diverse compounds, including 4252 mutagens and 3365 nonmutagens, was constructed and three models showed high and reliable predictive accuracy for theMutagenicity and could be used in prediction of chemical Ames mutagenicity.
Journal ArticleDOI
Network-Based Methods for Prediction of Drug-Target Interactions.
TL;DR: Network-based methods provide alternative tools for studies in drug repurposing, new drug discovery, systems pharmacology and systems toxicology, and their applications in a wide range of fields, including target prediction and elucidation of molecular mechanisms of therapeutic effects or safety problems are introduced.
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Association between cigarette smoking and Parkinson’s disease: A meta-analysis
TL;DR: The results demonstrated the inverse association between cigarette smoking and the risk of Parkinson's disease and suggested that effective drugs for PD might be developed using chemical substances derived from tobacco or tobacco smoke.