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Guixia Liu
Researcher at East China University of Science and Technology
Publications - 189
Citations - 7103
Guixia Liu is an academic researcher from East China University of Science and Technology. The author has contributed to research in topics: Medicine & Computer science. The author has an hindex of 34, co-authored 156 publications receiving 4954 citations. Previous affiliations of Guixia Liu include Chinese Academy of Sciences & East China Normal University.
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Computational Insights into Molecular Activation and Positive Cooperative Mechanisms of FFAR1 Modulators.
TL;DR: Simulation of free fatty acid receptor 1 systems revealed that the hydrophobic layer amino acid residues next to the transmission switch formed a gate and could open only upon agonist activation, which might exert an important role in the formation of water pathway.
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Insights into the Molecular Mechanisms of Liuwei Dihuang Decoction via Network Pharmacology.
TL;DR: Based on a novel network pharmacology-based approach, this article explored the potential therapeutic targets of Liuwei Dihuang (LWDH) decoction in its neuroendocrine immunomodulation (NIM) function.
Journal Article
[Protective effects of (-)-S.R-daurisoline on neuronal injury in rat primary cortical cultures].
TL;DR: The experimental results demonstrated that (-)-S.R-daurisoline could obviously inhibit the neurotoxicity induced by glutamate and significantly increased cell viability in dose-dependent manner and may be relevant to inhibit Ca2+ influx into cells via glutamate-mediated ligand-gated ion channels.
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Discovery of New Estrogen-Related Receptor α Agonists via a Combination Strategy Based on Shape Screening and Ensemble Docking
TL;DR: This study identified the novel potent ERR α agonists or an inverse agonist that would be the promising starting point for further exploration and demonstrated a successful molecular dynamics-guided approach applicable in virtual screening for ERRα agonists.