G
Gunther Bal
Researcher at University of Antwerp
Publications - 21
Citations - 1119
Gunther Bal is an academic researcher from University of Antwerp. The author has contributed to research in topics: Nucleoside & Hydrolase. The author has an hindex of 13, co-authored 20 publications receiving 1063 citations.
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Journal ArticleDOI
Kinetic Investigation of Chemokine Truncation by CD26/Dipeptidyl Peptidase IV Reveals a Striking Selectivity within the Chemokine Family
Anne-Marie Lambeir,Paul Proost,Christine Durinx,Gunther Bal,Kristel Senten,Koen Augustyns,Simon Scharpé,Jo Van Damme,Ingrid De Meester +8 more
TL;DR: The steady-state catalytic parameters for a relevant selection of chemokines previously reported to alter their chemotactic behavior due to CD26/dipeptidyl peptidase IV-catalyzed truncation are determined and reveal a striking selectivity for stromal cell-derived factor-1α (CXCL12) and macrophage-derived chemokine (CCL22).
Journal ArticleDOI
Truncation of Macrophage-derived Chemokine by CD26/ Dipeptidyl-Peptidase IV beyond Its Predicted Cleavage Site Affects Chemotactic Activity and CC Chemokine Receptor 4 Interaction
Paul Proost,Sofie Struyf,Dominique Schols,Ghislain Opdenakker,Silvano Sozzani,Paola Allavena,Alberto Mantovani,Koen Augustyns,Gunther Bal,Achiel Haemers,Anne-Marie Lambeir,Simon Scharpé,Jo Van Damme,Ingrid De Meester +13 more
TL;DR: NH2-terminal truncation of MDC by CD26/DPP IV has profound biological consequences and may be an important regulatory mechanism during the migration of Th2 lymphocytes and dendritic cells to germinal centers and to sites of inflammation.
Journal Article
The unique properties of dipeptidyl-peptidase IV (DPP IV / CD26) and the therapeutic potential of DPP IV inhibitors.
Koen Augustyns,Gunther Bal,G. Thonus,A. Belyaev,X. M. Zhang,W. Bollaert,Anne-Marie Lambeir,Christine Durinx,Filip Goossens,A. Haemers +9 more
TL;DR: In this paper, the properties and functions of dipeptidyl peptidase IV (DPP IV, EC 3.4.14.5) were discussed, and the role of CD26 in the intestinal and renal handling of proline containing peptides, in cell adhesion, in peptide metabolism, in the immune system and in HIV infection.
Journal ArticleDOI
The Unique Properties of Dipeptidyl-Peptidase IV (DPP IV / CD26) and the Therapeutic Potential of DPP IV Inhibitors
Koen Augustyns,Gunther Bal,G. Thonus,A. Belyaev,X. M. Zhang,W. Bollaert,Anne-Marie Lambeir,Christine Durinx,Filip Goossens,A. Haemers +9 more
TL;DR: The latest developments in the search for new inhibitors will be reported as well as the discovery of new natural substrates for DPP IV such as the glucagon-like peptides and the chemokines.
Journal ArticleDOI
Study of a new rate increasing "base effect" in the palladium-catalyzed amination of aryl iodides.
Caroline Meyers,Bert U. W. Maes,Kristof T. J. Loones,Gunther Bal,Guy L. F. Lemiere,Roger Dommisse +5 more
TL;DR: A general protocol for the intermolecular amination of aryl iodides with all types of amines has been developed based on a standard Pd-BINAP catalyst, using cesium carbonate as the base.