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Guo Li Ming
Researcher at University of Pennsylvania
Publications - 297
Citations - 41888
Guo Li Ming is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Neurogenesis & Neural stem cell. The author has an hindex of 88, co-authored 260 publications receiving 35776 citations. Previous affiliations of Guo Li Ming include Florida State University & Emory University.
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Journal ArticleDOI
Adult neurogenesis in the mammalian brain: significant answers and significant questions.
Guo Li Ming,Hongjun Song +1 more
TL;DR: Major advances in understanding of adult mammalian neurogenesis in the dentate gyrus of the hippocampus and from the subventricular zone of the lateral ventricle, the rostral migratory stream to the olfactory bulb are reviewed.
Journal ArticleDOI
Adult neurogenesis in the mammalian central nervous system
Guo Li Ming,Hongjun Song +1 more
TL;DR: Advances in the understanding of adult neurogenesis will not only shed light on the basic principles of adult plasticity, but also may lead to strategies for cell replacement therapy after injury or degenerative neurological diseases.
Journal ArticleDOI
Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure
Xuyu Qian,Ha Nam Nguyen,Mingxi M. Song,Christopher Hadiono,Sarah C. Ogden,Christy Hammack,Bing Yao,Gregory R. Hamersky,Fadi Jacob,Chun Zhong,Ki Jun Yoon,William J. Jeang,Li Lin,Yujing Li,Jai Thakor,Daniel A. Berg,Ce Zhang,Eunchai Kang,Michael Chickering,David W. Nauen,Cheng-Ying Ho,Cheng-Ying Ho,Zhexing Wen,Kimberly M. Christian,Pei Yong Shi,Brady J. Maher,Hao Wu,Peng Jin,Hengli Tang,Hongjun Song,Guo Li Ming +30 more
TL;DR: A miniaturized spinning bioreactor (SpinΩ) is developed to generate forebrain-specific organoids from human iPSCs that recapitulate key features of human cortical development, including progenitor zone organization, neurogenesis, gene expression, and, notably, a distinct human-specific outer radial glia cell layer.
Journal ArticleDOI
Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain
TL;DR: This study suggests a TET1-induced oxidation-deamination mechanism for active DNA demethylation in mammals.
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Distinct Morphological Stages of Dentate Granule Neuron Maturation in the Adult Mouse Hippocampus
TL;DR: The study reveals the key morphological transitions of newborn granule neurons during their course of maturation and shows that the morphological maturation is differentially affected by age and experience, as shown by comparisons between adult and postnatal brains and between housing conditions.