Guo-Xiang Zhou

TL;DR: Interestingly, it is found that autophagy in Sertoli cells was activated in Cd-treated WT mouse testes as evidenced by the increment of LC3 puncta surrounding SOX9, a specific SERToli cell marker.

TL;DR: In this article, the role of placental mitophagy in Cd-impaired fetal growth was explored in vitro and in vivo experiments to investigate the effect of Cd on placental trophoblasts.

TL;DR: In this article, a neoteric mechanism was proposed to protect against environmental stress-impaired P4 synthesis and fetal growth via suppressing ROS-mediated GCN2/ATF4/BNIP3-dependent mitophagy in placental trophoblasts.

TL;DR: Parkin siRNA (siR) and MG132, an inhibitor for proteasome, abolished MCL-1 degradation in Cd-stimulated cells in placental trophoblasts as mentioned in this paper.

TL;DR: In this article, the effects of gestational exposure to N-acetylcysteine (NAC), a free-radical scavenging antioxidant, presented that NAC supplementation alleviated hepatic oxidative stress in fetuses, and thereby reversed hyperglycemia and glucose intolerance in mouse offspring.