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Guoqing Zhu
Researcher at Tongji University
Publications - 21
Citations - 817
Guoqing Zhu is an academic researcher from Tongji University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 11, co-authored 16 publications receiving 508 citations.
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Journal ArticleDOI
circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma.
Xiao Zhang,Yanfeng Xu,Zijun Qian,Weisheng Zheng,Qi Wu,Yan Chen,Guoqing Zhu,Ya Liu,Zhixuan Bian,Wen Xu,Yue Zhang,Fenyong Sun,Qiuhui Pan,Jiayi Wang,Lutao Du,Yongchun Yu +15 more
TL;DR: It is determined that circ_104075 was highly expressed in HCC and its upstream and downstream regulatory mechanisms are elucidated and it has the potential to serve as a new diagnostic biomarker in H CC.
Journal ArticleDOI
The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis
Xiao Zhang,Yongxia Qiao,Qi Wu,Yan Chen,Shaowu Zou,Xiangfan Liu,Guoqing Zhu,Yinghui Zhao,Yuxin Chen,Yongchun Yu,Qiuhui Pan,Jiayi Wang,Fenyong Sun +12 more
TL;DR: It is found via in vitro cell-based and in vivo mouse model experiments that O-GlcNAcylation of YAP was required for high-glucose-induced liver tumorigenesis and is a potential therapeutic intervention point for treating liver cancer associated with high blood glucose levels and possibly diabetes.
Journal ArticleDOI
Ferroptosis is governed by differential regulation of transcription in liver cancer
Xiao Zhang,Lutao Du,Yongxia Qiao,Xiaobai Zhang,Weisheng Zheng,Qi Wu,Yan Chen,Guoqing Zhu,Ya Liu,Zhixuan Bian,Susu Guo,Yueyue Yang,Lifang Ma,Yongchun Yu,Qiuhui Pan,Fenyong Sun,Jiayi Wang +16 more
TL;DR: Two categories of genes are identified: ferroptosis up-regulated factors (FUF) and FDF, which stimulate and suppress ferroPTosis by affecting the synthesis of GSH, and disrupting the balance between HIC1 and HNF4A might be helpful in treating liver cancer.
Journal ArticleDOI
Effects of exercise intervention in breast cancer survivors: a meta-analysis of 33 randomized controlled trails
TL;DR: The study suggested that exercise intervention was beneficial to breast cancer survivors, and exercise should be recommended to this patient group.
Journal ArticleDOI
CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.
Ya Liu,Xiao Zhang,Xiao Zhang,Jiafei Lin,Yuxin Chen,Yongxia Qiao,Susu Guo,Yueyue Yang,Guoqing Zhu,Qiuhui Pan,Jiayi Wang,Fenyong Sun +11 more
TL;DR: Seral-CCT3 was proven to be a potential biomarker, and its diagnostic capacity was better than that of alpha fetoprotein to a certain extent, and elevated levels of the CCT3-YAP-TFCP2 axis might be critical for liver malignancy.