V
Vincenzo Pirrotta
Researcher at Rutgers University
Publications - 55
Citations - 11852
Vincenzo Pirrotta is an academic researcher from Rutgers University. The author has contributed to research in topics: Chromatin & Gene. The author has an hindex of 37, co-authored 54 publications receiving 11152 citations. Previous affiliations of Vincenzo Pirrotta include University of Geneva & École normale supérieure de Lyon.
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Journal ArticleDOI
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites.
TL;DR: Histone H3 methylated in vitro by the E(Z)/ESC complex binds specifically to Polycomb protein, which is closely associated with Polycomb binding sites on polytene chromosomes but is also found in centric heterochromatin, chromosome 4, and telomeric sites.
Journal ArticleDOI
Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE
Sushmita Roy,Jason Ernst,Peter V. Kharchenko,Pouya Kheradpour,Nicolas Nègre,Matthew L. Eaton,Jane M. Landolin,Christopher A. Bristow,Lijia Ma,Michael F. Lin,Stefan Washietl,Bradley I. Arshinoff,Ferhat Ay,Patrick E. Meyer,Nicolas Robine,Nicole L. Washington,Luisa Di Stefano,Eugene Berezikov,Christopher D. Brown,Rogerio Candeias,Joseph W. Carlson,Adrian Carr,Irwin Jungreis,Daniel Marbach,Rachel Sealfon,Michael Y. Tolstorukov,Sebastian Will,Artyom A. Alekseyenko,Carlo G. Artieri,Benjamin W. Booth,Angela N. Brooks,Qi Dai,Carrie A. Davis,Michael O. Duff,X. Feng,Andrey A. Gorchakov,Tingting Gu,Jorja G. Henikoff,Philipp Kapranov,Renhua Li,Heather K. MacAlpine,John H. Malone,Aki Minoda,Jared T. Nordman,Katsutomo Okamura,Marc D. Perry,Sara K. Powell,Nicole C. Riddle,Akiko Sakai,Anastasia Samsonova,Jeremy E. Sandler,Yuri B. Schwartz,Noa Sher,Rebecca Spokony,David Sturgill,Marijke J. van Baren,Kenneth H. Wan,Li Yang,Charles Yu,Elise A. Feingold,Peter J. Good,Mark S. Guyer,Rebecca F. Lowdon,Kami Ahmad,Justen Andrews,Bonnie Berger,Steven E. Brenner,Michael R. Brent,Lucy Cherbas,Sarah C. R. Elgin,Thomas R. Gingeras,Robert L. Grossman,Roger A. Hoskins,Thomas C. Kaufman,W. J. Kent,Mitzi I. Kuroda,Terry L. Orr-Weaver,Norbert Perrimon,Vincenzo Pirrotta,James W. Posakony,Bing Ren,Steven Russell,Peter Cherbas,Brenton R. Graveley,Suzanna E. Lewis,Gos Micklem,Brian Oliver,Peter J. Park,Susan E. Celniker,Steven Henikoff,Gary H. Karpen,Eric C. Lai,David M. MacAlpine,Lincoln Stein,Kevin P. White,Manolis Kellis +95 more
TL;DR: The Drosophila Encyclopedia of DNA Elements (modENCODE) project as mentioned in this paper has been used to map transcripts, histone modifications, chromosomal proteins, transcription factors, replication proteins and intermediates, and nucleosome properties across a developmental time course and in multiple cell lines.
Journal ArticleDOI
Role of the polycomb protein EED in the propagation of repressive histone marks
Raphaël Margueron,Neil Justin,Katsuhito Ohno,Miriam Sharpe,Jinsook Son,William J. Drury,Philipp Voigt,Stephen R. Martin,William R. Taylor,Valeria De Marco,Vincenzo Pirrotta,Danny Reinberg,Steven J. Gamblin +12 more
TL;DR: It is shown that the carboxy-terminal domain of EED specifically binds to histone tails carrying trimethyl-lysine residues associated with repressive chromatin marks, and that this leads to the allosteric activation of the methyltransferase activity of PRC2.
Journal ArticleDOI
Polycomb silencing mechanisms and the management of genomic programmes.
TL;DR: Polycomb group complexes, which are known to regulate homeotic genes, have been found to control hundreds of other genes in mammals and insects, and function as global enforcers of epigenetically repressed states.
Journal ArticleDOI
Comprehensive analysis of the chromatin landscape in Drosophila melanogaster
Peter V. Kharchenko,Artyom A. Alekseyenko,Artyom A. Alekseyenko,Yuri B. Schwartz,Aki Minoda,Nicole C. Riddle,Jason Ernst,Jason Ernst,Peter J. Sabo,Erica Larschan,Erica Larschan,Erica Larschan,Andrey A. Gorchakov,Andrey A. Gorchakov,Tingting Gu,Daniela Linder-Basso,Annette Plachetka,Annette Plachetka,Gregory A. Shanower,Michael Y. Tolstorukov,Michael Y. Tolstorukov,Lovelace J. Luquette,Ruibin Xi,Youngsook L. Jung,Youngsook L. Jung,Richard W. Park,Richard W. Park,Eric P. Bishop,Eric P. Bishop,Theresa K. Canfield,Richard Sandstrom,Robert E. Thurman,David M. MacAlpine,John A. Stamatoyannopoulos,Manolis Kellis,Manolis Kellis,Sarah C. R. Elgin,Mitzi I. Kuroda,Mitzi I. Kuroda,Vincenzo Pirrotta,Gary H. Karpen,Peter J. Park,Peter J. Park,Peter J. Park +43 more
TL;DR: In this article, the authors present a genome-wide chromatin landscape for Drosophila melanogaster based on eighteen histone modifications, summarized by nine prevalent combinatorial patterns.