G
Guy Bar-Klein
Researcher at Johns Hopkins University School of Medicine
Publications - 15
Citations - 972
Guy Bar-Klein is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Epilepsy & Epileptogenesis. The author has an hindex of 12, co-authored 15 publications receiving 769 citations. Previous affiliations of Guy Bar-Klein include Ben-Gurion University of the Negev & Howard Hughes Medical Institute.
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Journal ArticleDOI
Transcriptome Profiling Reveals TGF-β Signaling Involvement in Epileptogenesis
Luisa P. Cacheaux,Sebastian Ivens,Yaron David,Alexander J Lakhter,Guy Bar-Klein,Michael Y. Shapira,Uwe Heinemann,Alon Friedman,Daniela Kaufer +8 more
TL;DR: The present data identifies the TGF-β pathway as a novel putative epileptogenic signaling cascade and therapeutic target for the prevention of injury-induced epilepsy.
Journal ArticleDOI
Losartan prevents acquired epilepsy via TGF‐β signaling suppression
Guy Bar-Klein,Luisa P. Cacheaux,Lyn Kamintsky,Ofer Prager,Itai Weissberg,Karl Schoknecht,Paul Cheng,Sooyoung Kim,Lydia Wood,Uwe Heinemann,Daniela Kaufer,Alon Friedman +11 more
TL;DR: This work investigated albumin‐mediated TGF‐β signaling and tested the efficacy of blocking the TGF-β pathway in preventing epilepsy and found it to be safe and effective.
Journal ArticleDOI
Imaging blood–brain barrier dysfunction as a biomarker for epileptogenesis
Guy Bar-Klein,Svetlana Lublinsky,Lyn Kamintsky,Iris Noyman,Iris Noyman,Ronel Veksler,Hotjensa Dalipaj,Vladimir V. Senatorov,Evyatar Swissa,Dror Rosenbach,Netta Elazary,Dan Z. Milikovsky,Nadav Milk,Michael Kassirer,Yossi Rosman,Yossi Rosman,Yonatan Serlin,Arik Eisenkraft,Arik Eisenkraft,Arik Eisenkraft,Yoash Chassidim,Yisrael Parmet,Daniela Kaufer,Alon Friedman,Alon Friedman +24 more
TL;DR: Results show that early blood-brain barrier pathology in the piriform network is a sensitive and specific predictor for epilepsy, while diffused pathology is associated with a lower risk.
Journal ArticleDOI
Paroxysmal slow cortical activity in Alzheimer’s disease and epilepsy is associated with blood-brain barrier dysfunction
Dan Z. Milikovsky,Jonathan Ofer,Vladimir V. Senatorov,Vladimir V. Senatorov,Aaron R. Friedman,Ofer Prager,Liron Sheintuch,Netta Elazari,Ronel Veksler,Daniel Zelig,Itai Weissberg,Guy Bar-Klein,Evyatar Swissa,Erez Hanael,Gal Ben-Arie,Osnat Schefenbauer,Lyna Kamintsky,Rotem Saar-Ashkenazy,Rotem Saar-Ashkenazy,Ilan Shelef,Merav H. Shamir,Ilan Goldberg,Amir Glik,Amir Glik,Felix Benninger,Felix Benninger,Daniela Kaufer,Daniela Kaufer,Alon Friedman,Alon Friedman +29 more
TL;DR: Electroencephalogram data from patients with Alzheimer’s disease is analyzed and an EEG signature of transient slowing of the cortical network that is termed paroxysmal slow wave events (PSWEs) is found, suggesting BBB pathology as an underlying mechanism and as a promising therapeutic target.
Journal ArticleDOI
Isoflurane prevents acquired epilepsy in rat models of temporal lobe epilepsy.
Guy Bar-Klein,Rebecca Klee,Claudia Brandt,Marion Bankstahl,Pablo Bascuñana,Kathrin Töllner,Hotjensa Dalipaj,Jens P. Bankstahl,Alon Friedman,Alon Friedman,Wolfgang Löscher +10 more
TL;DR: Novel preclinical findings with isoflurane are reported, which exerts various nonanesthetic effects that may be relevant for antiepileptogenesis.