G
Guy Lampe
Researcher at Princess Alexandra Hospital
Publications - 27
Citations - 720
Guy Lampe is an academic researcher from Princess Alexandra Hospital. The author has contributed to research in topics: Medicine & Chronic liver disease. The author has an hindex of 12, co-authored 22 publications receiving 538 citations.
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Journal ArticleDOI
Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis
Katia Nones,Katia Nones,Nicola Waddell,Nicola Waddell,Nicci Wayte,Ann-Marie Patch,Peter Bailey,Felicity Newell,Oliver Holmes,Oliver Holmes,J. Lynn Fink,Michael C.J. Quinn,Yue Hang Tang,Guy Lampe,Kelly Quek,Kelly A. Loffler,Suzanne Manning,Senel Idrisoglu,David Miller,Qinying Xu,Qinying Xu,Nick Waddell,Peter Wilson,Timothy J. C. Bruxner,Angelika N. Christ,Ivon Harliwong,Craig Nourse,Ehsan Nourbakhsh,Matthew F Anderson,Stephen H. Kazakoff,Conrad Leonard,Conrad Leonard,Scott Wood,Scott Wood,Peter T. Simpson,Peter T. Simpson,Lynne Reid,Lynne Reid,Lutz Krause,Damian J. Hussey,David I. Watson,Reginald V. Lord,Derek J. Nancarrow,Wayne A. Phillips,David C. Gotley,B. Mark Smithers,David C. Whiteman,Nicholas K. Hayward,Peter J. Campbell,John V. Pearson,John V. Pearson,Sean M. Grimmond,Sean M. Grimmond,Andrew Barbour +53 more
TL;DR: Genomic catastrophes have a significant role in the malignant transformation of EAC, and Mutational signature analysis confirms that extreme genomic instability in EAC can be driven by somatic BRCA2 mutations.
Journal ArticleDOI
ELF score ≥9.8 indicates advanced hepatic fibrosis and is influenced by age, steatosis and histological activity
Kevin J. Fagan,Kevin J. Fagan,Carel J. Pretorius,Leigh U. Horsfall,Leigh U. Horsfall,Katharine M. Irvine,Urs Wilgen,Kihoon Choi,Linda M. Fletcher,Linda M. Fletcher,Jill Tate,Michelle Melino,Sharmin Nusrat,Gregory Miller,Andrew D. Clouston,Emma Ballard,Peter O'Rourke,Guy Lampe,Jacobus P.J. Ungerer,Elizabeth E. Powell,Elizabeth E. Powell +20 more
TL;DR: This study was designed to determine the diagnostic accuracy of the manufacturer's cut‐off value (≥9.8) in identifying advanced fibrosis.
Journal ArticleDOI
A Pragmatic Approach Identifies a High Rate of Nonalcoholic Fatty Liver Disease With Advanced Fibrosis in Diabetes Clinics and At-Risk Populations in Primary Care
Preya J. Patel,Fabrina Hossain,Leigh U. Horsfall,Xuan Banh,Kelly L. Hayward,Suzanne Williams,T. J. Johnson,Anne Bernard,Nigel N. Brown,Guy Lampe,Lyndall Buck,Nivene Saad,Anthony W. Russell,Patricia C. Valery,Katharine M. Irvine,Andrew D. Clouston,Katherine A. Stuart,William Rosenberg,Elizabeth E. Powell +18 more
TL;DR: It is confirmed that LSM accuracy is influenced by severe obesity, whereas age impacts the ELF test, and further studies are required to confirm whether combining LSM and ELF may enhance accuracy and confidence in identifying clinically significant fibrosis.
Journal ArticleDOI
The Enhanced liver fibrosis score is associated with clinical outcomes and disease progression in patients with chronic liver disease
Katharine M. Irvine,Leesa F. Wockner,Mihir Shanker,Kevin J. Fagan,Kevin J. Fagan,Leigh U. Horsfall,Leigh U. Horsfall,Linda M. Fletcher,Jacobus P.J. Ungerer,Carel J. Pretorius,Gregory Miller,Andrew D. Clouston,Guy Lampe,Elizabeth E. Powell,Elizabeth E. Powell +14 more
TL;DR: Whether the serum‐based ELF (Enhanced Liver Fibrosis) test predicted liver‐related clinical outcomes, or progression to advanced liver disease, is investigated to compare the performance of ELF to liver biopsy and non‐invasive algorithms.
Journal ArticleDOI
Identification of the CIMP-like subtype and aberrant methylation of members of the chromosomal segregation and spindle assembly pathways in esophageal adenocarcinoma
Lutz Krause,Katia Nones,Kelly A. Loffler,Derek J. Nancarrow,Harald Oey,Yue Hang Tang,Nicola Wayte,Ann-Marie Patch,Kalpana Patel,Sandra Brosda,Suzanne Manning,Guy Lampe,Andrew D. Clouston,Janine Thomas,Jens Stoye,Damian J. Hussey,David I. Watson,Reginald V. Lord,Wayne A. Phillips,David C. Gotley,B. Mark Smithers,David C. Whiteman,Nicholas K. Hayward,Sean M. Grimmond,Nicola Waddell,Nicola Waddell,Andrew Barbour +26 more
TL;DR: Genes aberrantly methylated suggest a mechanism that could lead to genomic instability and chromothripsis and a CpG island methylator phenotype-like subtype with potentially worse clinical outcome was identified.