K
Kelly A. Loffler
Researcher at Flinders University
Publications - 48
Citations - 1459
Kelly A. Loffler is an academic researcher from Flinders University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 16, co-authored 29 publications receiving 1169 citations. Previous affiliations of Kelly A. Loffler include University of Adelaide & University of Queensland.
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Journal ArticleDOI
Etiology of ovarian failure in blepharophimosis ptosis epicanthus inversus syndrome: FOXL2 is a conserved, early-acting gene in vertebrate ovarian development.
TL;DR: The observations suggest that BPES may result from early abnormalities in regulating the development of the fetal ovary, rather than premature degeneration of the postnatal or adult Ovary, and the results suggest that FOXL2 is a highly conserved early regulator of vertebrate ovarian development.
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Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis
Katia Nones,Katia Nones,Nicola Waddell,Nicola Waddell,Nicci Wayte,Ann-Marie Patch,Peter Bailey,Felicity Newell,Oliver Holmes,Oliver Holmes,J. Lynn Fink,Michael C.J. Quinn,Yue Hang Tang,Guy Lampe,Kelly Quek,Kelly A. Loffler,Suzanne Manning,Senel Idrisoglu,David Miller,Qinying Xu,Qinying Xu,Nick Waddell,Peter Wilson,Timothy J. C. Bruxner,Angelika N. Christ,Ivon Harliwong,Craig Nourse,Ehsan Nourbakhsh,Matthew F Anderson,Stephen H. Kazakoff,Conrad Leonard,Conrad Leonard,Scott Wood,Scott Wood,Peter T. Simpson,Peter T. Simpson,Lynne Reid,Lynne Reid,Lutz Krause,Damian J. Hussey,David I. Watson,Reginald V. Lord,Derek J. Nancarrow,Wayne A. Phillips,David C. Gotley,B. Mark Smithers,David C. Whiteman,Nicholas K. Hayward,Peter J. Campbell,John V. Pearson,John V. Pearson,Sean M. Grimmond,Sean M. Grimmond,Andrew Barbour +53 more
TL;DR: Genomic catastrophes have a significant role in the malignant transformation of EAC, and Mutational signature analysis confirms that extreme genomic instability in EAC can be driven by somatic BRCA2 mutations.
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The coactivator-associated arginine methyltransferase is necessary for muscle differentiation - CARM1 coactivates myocyte enhancer factor-2
TL;DR: This work clearly demonstrates that the arginine methyltransferase CARM1 potentiates myogenesis and supports the positive role of arginin methylation in mammalian differentiation.
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Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues.
Christine A. Biondi,Michael Gartside,Paul Waring,Kelly A. Loffler,Mitchell S. Stark,Mark A. Magnuson,Graham F. Kay,Nicholas K. Hayward +7 more
TL;DR: Conditional homozygous inactivation of the Men1 gene in the pituitary gland and endocrine pancreas bypasses the embryonic lethality associated with a constitutional Men1 −/− genotype and leads to β-cell hyperplasia in less than 4 months and insulinomas and prolactinomas starting at 9 months.
Journal ArticleDOI
Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1.
Kelly A. Loffler,Christine A. Biondi,Michael Gartside,Paul Waring,Mitchell S. Stark,Magdalena M. Serewko-Auret,H. Konrad Muller,Nicholas K. Hayward,Graham F. Kay +8 more
TL;DR: Menin expression was below the level of detection in ovary, thyroid and testis, but loss of nuclear menin immunoreactivity was observed uniformly in all pancreatic islet adenomas and in some hyperplastic islet cells, suggesting that complete loss of Men1 is a critical point in islet tumor progression in this model.