G
Gwen Liu
Researcher at Stanford University
Publications - 6
Citations - 2211
Gwen Liu is an academic researcher from Stanford University. The author has contributed to research in topics: Gene silencing & microRNA. The author has an hindex of 6, co-authored 6 publications receiving 2102 citations.
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Journal ArticleDOI
miR-181a is an intrinsic modulator of T cell sensitivity and selection
Qi-Jing Li,Jacqueline Chau,Peter J.R. Ebert,Giselle Sylvester,Hyeyoung Min,Gwen Liu,Ravi Braich,Muthiah Manoharan,Juergen Soutschek,Petra Skare,Lawrence O. Klein,Mark M. Davis,Chang-Zheng Chen +12 more
TL;DR: It is shown that increasing miR-181a expression in mature T cells augments the sensitivity to peptide antigens, while inhibition in the immature T cells reduces sensitivity and impairs both positive and negative selection.
Journal ArticleDOI
Micromanagement of the immune system by microRNAs
TL;DR: An overview of the mechanisms by which miRNAs regulate gene expression is provided, with specific focus on the role ofmiRNAs in regulating the development of immune cells and in modulating innate and adaptive immune responses.
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Erratum: Micromanagement of the immune system by microRNAs
TL;DR: The authors for reference 97 were published incorrectly and the text should have read: Wu, H. et al.
Journal ArticleDOI
Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia.
Diana Schotte,Jacqueline Chau,Giselle Sylvester,Gwen Liu,Caifu Chen,V H J van der Velden,Mathilde J.C. Broekhuis,T C J M Peters,Rob Pieters,M L den Boer +9 more
TL;DR: It is shown that miRNA expression profiles are ALL subtype-specific rather than linked to the differentiation stadium associated with these subtypes.
Journal ArticleDOI
Pre-miRNA loop nucleotides control the distinct activities of mir-181a-1 and mir-181c in early T cell development.
TL;DR: It is demonstrated that pre-miRNA loop nucleotides play a critical role in controlling the activity of miRNA genes and that members of the same miRNA gene families could have evolved to achieve different activities via alterations in their pre- miRNA loop sequences, while maintaining identical or nearly identical mature miRNA sequences.