Gwyn A. Lord

TL;DR: The applications of LC-MS to the studies of in vitro and in vivo drug metabolism, identification and characterization of impurities in pharmaceuticals, analysis of chiral impurity in drug substances and high-throughputLC-MS-MS systems for applications in the "accelerated drug discovery" process are described.

TL;DR: The levels of certain low molecular weight anions usually associated with intermediary metabolism were found to be significantly elevated in the plasma ultrafiltrate obtained from patients with metabolic acidosis, suggesting that these hitherto unmeasured anions may contribute to the generation of the anion gap in patients with lactic acidosis and acidosis of unknown aetiology and may be underestimated in diabetic ketoacidosis.

TL;DR: The results suggest that a dihydropyrone-substituted steroid is an endogenous regulator of the sodium pump in humans and, presumably, other mammals.

TL;DR: Tapered and narrow restrictor capillaries have been investigated for use in capillary electrochromatography (CEC) and have been shown to offer viable, more reproducible, alternatives to silica frits and may aid in suppression of bubble formation, a recognised problem in CEC as mentioned in this paper.

TL;DR: A capillary zone electrophoretic method for the rapid analysis of the major alkaloids (arecoline and guavacoline) in areca nut extract is described and is applicable to the analysis of alkaloid in the nut, commercial preparations and in the saliva of areca Nut chewers.