Institution
Worthing Hospital
Healthcare•Worthing, United Kingdom•
About: Worthing Hospital is a healthcare organization based out in Worthing, United Kingdom. It is known for research contribution in the topics: Patient satisfaction & Health care. The organization has 648 authors who have published 542 publications receiving 16131 citations.
Topics: Patient satisfaction, Health care, Randomized controlled trial, Inguinal hernia, Caesarean section
Papers published on a yearly basis
Papers
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TL;DR: This review presents issues arising from an analysis of over 100 papers published in the field of patient satisfaction, reflecting changes in service management especially in the U.K. and U.S.A. over the past decade.
1,721 citations
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TL;DR: The identification of T cell responses associated with milder disease will support an understanding of protective immunity and highlights the potential of including non-spike proteins within future COVID-19 vaccine design.
Abstract: The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery from COVID-19 (28 with mild disease and 14 with severe disease) and 16 unexposed donors, using interferon-γ-based assays with peptides spanning SARS-CoV-2 except ORF1. The breadth and magnitude of T cell responses were significantly higher in severe as compared with mild cases. Total and spike-specific T cell responses correlated with spike-specific antibody responses. We identified 41 peptides containing CD4+ and/or CD8+ epitopes, including six immunodominant regions. Six optimized CD8+ epitopes were defined, with peptide–MHC pentamer-positive cells displaying the central and effector memory phenotype. In mild cases, higher proportions of SARS-CoV-2-specific CD8+ T cells were observed. The identification of T cell responses associated with milder disease will support an understanding of protective immunity and highlights the potential of including non-spike proteins within future COVID-19 vaccine design. Questions have arisen as to whether patients with severe COVID-19 disease can generate a T cell response against SARS-CoV-2. Tao Dong and colleagues report that convalescent patients with COVID-19 harbor functional memory CD4+ and CD8+ T cells that recognize multiple epitopes that span the viral proteome. CD4+ T cells predominated the memory response in patients with severe disease, whereas higher proportions of CD8+ T cells were found in patients with mild disease.
982 citations
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TL;DR: In this paper, a structure-function analysis of B.1.351 was performed using a large cohort of convalescent and vaccinee serum samples, and it was shown that the receptor-binding domain mutations provide tighter ACE2 binding and widespread escape from monoclonal antibody neutralization largely driven by E484K, although K417N and N501Y act together against some important antibody classes.
831 citations
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TL;DR: Intraoperative oesophageal Doppler guided fluid management was associated with a 1.5-day median reduction in postoperative hospital stay and patients recovered gut function significantly faster and suffered significantly less gastrointestinal and overall morbidity.
Abstract: Background Occult hypovolaemia is a key factor in the aetiology of postoperative morbidity and may not be detected by routine heart rate and arterial pressure measurements. Intraoperative gut hypoperfusion during major surgery is associated with increased morbidity and postoperative hospital stay. We assessed whether using intraoperative oesophageal Doppler guided fluid management to minimize hypovolaemia would reduce postoperative hospital stay and the time before return of gut function after colorectal surgery. Methods This single centre, blinded, prospective controlled trial randomized 128 consecutive consenting patients undergoing colorectal resection to oesophageal Doppler guided or central venous pressure (CVP)-based (conventional) intraoperative fluid management. The intervention group patients followed a dynamic oesophageal Doppler guided fluid protocol whereas control patients were managed using routine cardiovascular monitoring aiming for a CVP between 12 and 15 mm Hg. Results The median postoperative stay in the Doppler guided fluid group was 10 vs 11.5 days in the control group P Conclusions Intraoperative oesophageal Doppler guided fluid management was associated with a 1.5-day median reduction in postoperative hospital stay. Patients recovered gut function significantly faster and suffered significantly less gastrointestinal and overall morbidity.
588 citations
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TL;DR: Invasive intraoperative haemodynamic monitoring with fluid challenges during repair of femoral fracture under general anaesthetic shortens time to being medically fit for discharge, and postoperative recovery for survivors was significantly faster.
Abstract: Background A prospective, randomized controlled trial comparing conventional intraoperative fluid management with two differing methods of invasive haemodynamic monitoring to optimize intraoperative fluid therapy, in patients undergoing proximal femoral fracture repair under general anaesthesia. Methods Ninety patients randomized to three groups; conventional intraoperative fluid management (Gp CON, n=29), and two groups receiving additional repeated colloid fluid challenges guided by central venous pressure (Gp CVP, n=31) or oesophageal Doppler ultrasonography (Gp DOP, n=30). Primary outcome measures were time to medical fitness to discharge, hospital stay and postoperative morbidity. Results The fluid challenge resulted in significantly greater perioperative changes in central venous pressure between Gp CVP and Gp CON (mean 5 (95% confidence interval 3–7) mm Hg) (P Conclusions Invasive intraoperative haemodynamic monitoring with fluid challenges during repair of femoral fracture under general anaesthetic shortens time to being medically fit for discharge.
459 citations
Authors
Showing all 649 results
Name | H-index | Papers | Citations |
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Mohamed H. Sayegh | 103 | 485 | 38540 |
Lui G. Forni | 32 | 152 | 5809 |
Mirza K. Baig | 27 | 60 | 2072 |
Muhammad S. Sajid | 27 | 62 | 1948 |
Cyrill A. Rentsch | 23 | 67 | 2205 |
Elizabeth Cheek | 19 | 37 | 1260 |
Ankur Arora | 17 | 103 | 772 |
John Sitzia | 16 | 17 | 3136 |
P. Sains | 13 | 21 | 711 |
Luke Hodgson | 13 | 44 | 862 |
Neruban Kumaran | 12 | 34 | 519 |
Laurentiu Craciunas | 12 | 30 | 415 |
Rhona Buckingham | 12 | 22 | 767 |
Gordon Caldwell | 12 | 31 | 717 |
Krishna K. Singh | 11 | 21 | 323 |