H
H Asita de Silva
Researcher at University of Kelaniya
Publications - 34
Citations - 1208
H Asita de Silva is an academic researcher from University of Kelaniya. The author has contributed to research in topics: Randomized controlled trial & Neuroaid. The author has an hindex of 14, co-authored 29 publications receiving 822 citations. Previous affiliations of H Asita de Silva include University of Oxford.
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Journal ArticleDOI
Adverse reactions to snake antivenom, and their prevention and treatment.
TL;DR: Doctors will have to depend on pharmacological prophylaxis, where the search for the bestProphylactic agent is still on-going, as well as careful observation of patients receiving antivenom in preparation for prompt management of acute and delayed reactions when they occur.
Journal ArticleDOI
Low-dose adrenaline, promethazine, and hydrocortisone in the prevention of acute adverse reactions to antivenom following snakebite: a randomised, double-blind, placebo-controlled trial.
H Asita de Silva,Arunasalam Pathmeswaran,Channa D Ranasinha,Shaluka Jayamanne,Senarath B. Samarakoon,Ariyasena Hittharage,Ranjith Kalupahana,G. Asoka Ratnatilaka,Wimalasiri Uluwatthage,Jeffrey K Aronson,Jane Armitage,David G. Lalloo,H. Janaka de Silva +12 more
TL;DR: In a factorial randomized trial conducted in Sri Lanka, de Silva and colleagues evaluate the safety and efficacy of pretreatments intended to reduce the risk of serious reactions to antivenom following snakebite.
Journal ArticleDOI
Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome: ODYSSEY OUTCOMES Trial.
J. Wouter Jukema,Michael Szarek,Laurien E Zijlstra,H Asita de Silva,Deepak L. Bhatt,Vera Bittner,Rafael Diaz,Jay M. Edelberg,Shaun G. Goodman,Corinne Hanotin,Robert A. Harrington,Yuri Karpov,Angele Moryusef,Robert Pordy,Juan Carlos Prieto,Matthew T. Roe,Harvey D. White,Andreas M. Zeiher,Gregory G. Schwartz,P. Gabriel Steg,Odyssey Outcomes Committees,Investigators +21 more
TL;DR: A large number of patients with acute coronary syndrome and concomitant noncoronary atherosclerosis have a high risk of major adverse cardiovascular events (MACEs) and death and the impact of lipid low ...
Journal ArticleDOI
Fixed Low-Dose Triple Combination Antihypertensive Medication vs Usual Care for Blood Pressure Control in Patients With Mild to Moderate Hypertension in Sri Lanka: A Randomized Clinical Trial.
Ruth Webster,Abdul Salam,H Asita de Silva,Vanessa Selak,Sandrine Stepien,Senaka Rajapakse,Stanley Amarasekara,Naomali Amarasena,Laurent Billot,Arjuna P. De Silva,Mervyn Fernando,Rama K Guggilla,Stephen Jan,Jayanthimala Jayawardena,Pallab K. Maulik,Sepalika Mendis,Suresh Mendis,Janake Munasinghe,Nitish Naik,Dorairaj Prabhakaran,Gotabaya Ranasinghe,Simon Thom,Nirmali Tisserra,Vajira Senaratne,Sanjeewa Wijekoon,Santharaj Wijeyasingam,Anthony Rodgers,Anushka Patel +27 more
TL;DR: Treatment with a pill containing low doses of 3 antihypertensive drugs led to an increased proportion of patients achieving their target BP goal vs usual care and use of such medication as initial therapy or to replace monotherapy may be an effective way to improve BP control.
Journal ArticleDOI
Cluster-Randomized, Crossover Trial of Head Positioning in Acute Stroke
Craig S. Anderson,Hisatomi Arima,Pablo M. Lavados,Laurent Billot,Maree L. Hackett,Verónica V. Olavarría,Paula Muñoz Venturelli,Alejandro M. Brunser,Bin Peng,Liying Cui,Lily Song,Lily Song,Kris Rogers,Sandy Middleton,Sandy Middleton,Joyce Y Lim,Denise Forshaw,C. Elizabeth Lightbody,Mark Woodward,Octavio M. Pontes-Neto,H Asita de Silva,Ruey-Tay Lin,Tsong-Hai Lee,Jeyaraj D Pandian,Gillian Mead,Thompson G. Robinson,Caroline L Watkins +26 more
TL;DR: In this paper, the role of supine positioning after acute stroke in improving cerebral blood flow and the countervailing risk of aspiration pneumonia have led to variation in head positioning in clinical practice.