Showing papers by "H. Bryan Brewer published in 1980"
TL;DR: Investigation of the effects of apolipoproteins C-II, C-III, and H on the enzymic activity of LPL provided evidence for the concept that the enzyme activity in triglyceride metabolism is modulated by apoH, a recently described protein constituent of triglyceride rich lipoproteins in human lymph and plasma.
148 citations
TL;DR: Under the conditions of this study in which diet and weight were controlled, exercise conditioning did not elevate HDL-cholesterol levels, and data are consistent with the concept that exercise conditioning may affect HDL via alterations in body weight.
74 citations
TL;DR: The solution properties of apolipoproteins have been investigated extensively by several laboratories over the past few years l-i and reviewed recently and in the present report they are summarized briefly.
Abstract: The solution properties of apolipoproteins have been investigated extensively by several laboratories over the past few years l-i and reviewed recently.* In the present report we shall summarize briefly the unique molecular properties of these proteins. The intramolecular and intermolecular interactions of apolipoproteins respond dramatically to mild perturbations in their environment and thus an analysis of their structure has yielded valuable insight into the forces responsible for the stability of macromolecules in aqueous solution. It should be stressed that although the molecular properties of apolipoproteins are complex, they are quite reproducible and in many cases predictable. In this review we shall emphasize three major features of the molecular properties of apolipoproteins:
24 citations
TL;DR: The mixed association between two self-associating systems, human apolipoproteins A-I and A-II, has been evaluated by fluorescence spectroscopy and sedimentation equilibrium, and the role of protein-protein versus protein-lipid interactions in the quaternary organization of plasma lipoproteins is discussed.
19 citations
15 citations
TL;DR: This method should facilitate the development of a totally automated system for the sequence analysis of peptides and proteins and represents the fastest, easiest, and most versatile single method for identification of these amino acid derivatives.
14 citations