H
H de Wet
Researcher at Stellenbosch University
Publications - 7
Citations - 979
H de Wet is an academic researcher from Stellenbosch University. The author has contributed to research in topics: ATP hydrolysis & Osteoblast. The author has an hindex of 7, co-authored 7 publications receiving 944 citations. Previous affiliations of H de Wet include Spanish National Research Council & University of Cape Town.
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Journal ArticleDOI
ATPase and Multidrug Transport Activities of the Overexpressed Yeast ABC Protein Yor1p
TL;DR: It is demonstrated that Yor1p drives an energy-dependent, proton uncoupler-insensitive, cellular extrusion of rhodamine B and that Pdr5p mediated the ATP-dependent translocation of similar drugs and phospholipids across the yeast cell membrane.
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Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters.
A. Di Pietro,G. Conseil,José M. Pérez-Victoria,G. Dayan,Hélène Baubichon-Cortay,Doriane Trompier,Emmanuelle Steinfels,Jean-Michel Jault,H de Wet,Mathias Maitrejean,Gilles Comte,Ahcène Boumendjel,Anne-Marie Mariotte,Charles Dumontet,David B. McIntosh,André Goffeau,Santiago Castanys,Francisco Gamarro,Denis Barron +18 more
TL;DR: This review shows that due to similarities in function and maybe in three-dimensional organization of the different transporters, common potential modulators have been found and constitute promising potentialmodulators of multidrug resistance.
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Glucocorticoids Induce Rapid Up-Regulation of Mitogen-Activated Protein Kinase Phosphatase-1 and Dephosphorylation of Extracellular Signal-Regulated Kinase and Impair Proliferation in Human and Mouse Osteoblast Cell Lines
TL;DR: MKP-1 up-regulation provides a novel and rapid mechanism, whereby GCs inhibit osteoblast proliferation, as well as indicating immediate-early gene phosphatase involvement, and used quantitative, real-time PCR to examine expression profiles of the dual-specificity MAPK phosphatases.
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A novel mutation causing DEND syndrome A treatable channelopathy of pancreas and brain
Kenju Shimomura,F. Horster,H de Wet,Se E. Flanagan,Sian Ellard,At T. Hattersley,Ni I. Wolf,Frances M. Ashcroft,F. Ebinger +8 more
TL;DR: A case of developmental delay, epilepsy, and neonatal diabetes (DEND) syndrome that shows neurologic improvement with sulfonylurea therapy is reported that may have considerable therapeutic benefit for the patient.
Journal ArticleDOI
Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain of mouse P-glycoprotein: structure-activity relationships for flavonoid binding
H de Wet,D B McIntosh,G. Conseil,Hélène Baubichon-Cortay,Tino Krell,J M Jault,Jean-Baptiste Daskiewicz,Denis Barron,A. Di Pietro +8 more
TL;DR: It can be concluded that the benzopyrone portion of the flavonoids binds at the adenyl site and the phenyl ring B at the ribosyl site in the ATP-binding site of mouse P-glycoprotein.