H
H F Bunn
Researcher at Brigham and Women's Hospital
Publications - 118
Citations - 19864
H F Bunn is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Hemoglobin & Erythropoietin. The author has an hindex of 59, co-authored 118 publications receiving 19438 citations. Previous affiliations of H F Bunn include Boston University & United States Department of the Army.
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The role of hemoglobin based blood substitutes in transfusion medicine
TL;DR: A cell-free oxygen transporting blood substitute would obviate many of the current concerns about conventional red cell transfusion therapy and have benefits and applications not possible withred cell transfusions, such as the treatment of acute hypovolemic shock in acute care settings.
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Association of hemoglobin H disease with Hb J-Iran (beta 77 His----Asp): impact on subunit assembly.
TL;DR: A young Iranian female found to be heterozygous for hemoglobin (Hb) J-Iran (beta 77 His----Asp) in combination with Hb H disease leads to a marked increase in the relative amount of the variant Hb within red cells, providing further support for an electrostatic model of Hb subunit assembly.
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Clinical evaluation of transfused blood after long-term storage in ACD with adenine.
TL;DR: Based on clinical laboratory findings, apparent lack of toxicity combined with adequate support of the bleeding patient suggest that blood stored in adenine is useful after longer storage periods than isBlood stored in plain ACD.
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Electrolyte composition and equilibrium in hemoglobin CC red blood cells.
TL;DR: The red cells of two patients with homozygous hemoglobin C disease (CC) were found to have reduced cation and water content when compared to the red cells Of two normal subjects that contained only hemoglobin A (AA), which is mainly due to a reduction in cell K content.
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Comments on the physics and chemistry of trehalose as a storage medium for hemoglobin-based blood substitutes: "from Kramers Theory to the Battlefield".
TL;DR: A glass of the naturally-occurring sugar trehalose may be a suitable medium for the storage of hemoglobin-based blood substitutes and the theoretical reasons for slowing of chemical reactions in the glassy state are discussed.