H F Bunn

TL;DR: Nonenzymatic glycosylation of lens crystallins exemplifies a new form of post-transitional modification of long-lived proteins in vivo and increases with age, particularly in HM alpha crystallin, a high molecular weight aggregate which accumulates with aging.

TL;DR: A cytosolic protein that binds specifically to Epo RNA was identified in the Epo-producing, hepatoblastoma Hep 3B cell line by gel mobility shift assay and binding activity was markedly increased in brain and spleen lysates from mice subjected to 24 h of hypoxia, suggesting the post-transcriptional regulation of Epo expression in response to hypoxIA may in part be due to the interaction of EpO RNA with its specific binding protein.

TL;DR: The results indicate that nonenzymatic glycosylation of hemoglobin in mammals is determined by three major variables: mean plasma glucose concentration, red cell life span, and red cell glucose permeability.

TL;DR: Functional studies show that the four native glycosylated minor components of human hemolysate possess unique functional properties which differ from those of the major component, Hb Ao.

TL;DR: In three patients with sickle-cell anemia who had been disabled by recurrent painful crises, sustained dilutional hyponatremia was induced by 1-desamino-8-D-arginine vasopressin (DDAVP) in combination with a high fluid intake.