Journal ArticleDOI
Further identification of the nature and linkage of the carbohydrate in hemoglobin A1c.
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It is found that Hb A1c contains neutral sugars which are only partially hydrolyzed from the N-termini of β chains, and it is proposed that in the red cell, glucose binds to the α-amino position of hemoglobin β-chains (valine) in an aldimine (Schiff base) linkage.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1975-11-03. It has received 421 citations till now. The article focuses on the topics: Mannose & Aldimine.read more
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Correlation of Glucose Regulation and Hemoglobin AIc in Diabetes Mellitus
Ronald J. Koenig,Charles M. Peterson,Robert L. Jones,Christopher Saudek,Mark L. Lehrman,Anthony Cerami +5 more
TL;DR: The periodic monitoring of hemoglobin AIc levels provides a useful way of documenting the degree of control of glucose metabolism in diabetic patients and provides a means whereby the relation of carbohydrate control to the development of sequelae can be assessed.
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The glycosylation of hemoglobin: relevance to diabetes mellitus
TL;DR: By providing an integrated measurement of blood glucose, hemoglobin AIc is useful in assessing the degree of diabetic control and is a useful model of nonenzymatic glycosylation of other proteins that may be involved in the long-term complications of the disease.
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Nonenzymatic browning in vivo: possible process for aging of long-lived proteins.
TL;DR: Although most proteins in living systems turn over with sufficient rapidity to avoid nonenzymatic browning, some, such as lens crystallins and skin collagen, are exceptionally long-lived and may be vulnerable.
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Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus
TL;DR: A review will highlight the involvement of AGEs in the development and progression of T2DM and their role in diabetic complications and the role of oxidative stress in hyperglycemia-induced tissue injury.
References
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Abnormal human haemoglobins. Separation and characterization of the alpha and beta chains by chromatography, and the determination of two new variants, hb Chesapeak and hb J (Bangkok).
TL;DR: In this article, a method for the separation of the α and β chains of human haemoglobin by chromatography on carboxymethyl-cellulose in 8 M -urea has been described.
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Hemoglobin components in patients with diabetes mellitus.
TL;DR: The increase in proportions of glycohemoglobin in diabetes mellitus appears to be another example of increased glycoproteins in this disorder.
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Observations on the Chromatographic Heterogeneity of Normal Adult and Fetal Human Hemoglobin: A Study of the Effects of Crystallization and Chromatography on the Heterogeneity and Isoleucine Content
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Studies of an unusual hemoglobin in patients with diabetes mellitus
TL;DR: Structural studies suggest the possibility that an amino sugar is bound to hemoglobin A1c in diabetic patients.