H R Horvitz

TL;DR: Neuronal cytoplasmic protein aggregation and defective RNA metabolism thus appear to be common pathogenic mechanisms involved in ALS and possibly in other neurodegenerative disorders.

TL;DR: The identification and characterization of genes that can be mutated to cause heterochrony support the proposal that heterochronsy is a mechanism for phylogenetic change and suggest cellular and genetic bases for heterochronic variation.

TL;DR: Exogenous serotonin and octopamine elicit specific and opposite behavioral responses in Caenorhabditis elegans, suggesting that these compounds function physiologically as antagonists.

TL;DR: Information suggests it will be productive to investigate other genetic determinants in amyotrophic lateral sclerosis and to use epidemiological characteristics of the disease to help discern molecular mechanisms of motor neuron cell death.

TL;DR: Five new genes are identified that play a role in eliminating cell corpses in the nematode Caenorhabditis elegans and electron microscopic studies reveal that mutations in each of these genes prevent engulfment, indicating that these genes are needed either for the recognition of corpses by other cells or for the initiation of phagocytosis.